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Enterome Highlights High Complete Response Rate in Clinical Study of EO2463 for Indolent Non-Hodgkin Lymphoma at ASCO 2024- Beneficial clinical responses observed with EO2463 monotherapy already at 6 weeks and complete response rate of 78% in patients treated with EO2463 upon addition of lenalidomide ± rituximab - EO2463 rapidly expands memory CD8+ T cells specific for OncoMimics™ peptides and B cell antigens evoking a fast and robust cytotoxic response that is maintained for up to 94 weeks - Expansion cohort evaluating EO2463 monotherapy in the “watch-and-wait” setting ongoing with initial results expected by end of 2024 PARIS, May 24, 2024 (GLOBE NEWSWIRE) -- Enterome, a clinical-stage company developing first-in-class immunomodulatory drugs for solid and liquid malignancies and inflammatory diseases based on its unique Mimicry platform, today announces updated immune-monitoring and clinical data from the ongoing EONHL1-20/SIDNEY trial evaluating EO2463 in monotherapy and in combination with lenalidomide and/or rituximab in indolent non-Hodgkin lymphoma (NHL). The results will be featured in a poster session on Monday, June 3rd, 2024, at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, USA. “We are extremely encouraged by these results, which validate our OncoMimics™ approach to targeting liquid tumors,” said Dr. Jan Fagerberg, Chief Medical Officer of Enterome. “In addition to the standalone activity seen with EO2463 during the first six weeks of treatment, the 78% complete response rate observed with the subsequent combination therapy supports our belief that EO2463 can significantly add to the patients’ care. Thanks to its unique safety and efficacy profiles, we believe EO2463 has the potential to become a valuable long-term treatment option for non-Hodgkin B cell lymphomas.” Pierre Bélichard, CEO of Enterome, added: “Building on the promising findings that are presented at ASCO 2024, we look forward to continuing the SIDNEY trial and reporting results from the monotherapy expansion cohort which focuses on the “watch-and-wait” setting. Despite a confirmed cancer diagnosis and being ultimately likely to progress to symptomatic condition, a large portion of patients with indolent Follicular Lymphoma and Marginal Zone Lymphoma are not receiving immediate treatment due to the lack of safe and effective therapies. EO2463 appears ideally suited to address this significant unmet medical need.” Key Highlights from the EONHL1-20/SIDNEY presentation, entitled Phase 1/2 of EO2463 immunotherapy as monotherapy and in combination with lenalidomide and/or rituximab in indolent NHL: The Phase 1/2 EONHL1-20/SIDNEY evaluates the safety and preliminary efficacy of EO2463 as monotherapy and in combination with lenalidomide and/or rituximab for the treatment of patients with indolent NHL. Patients in cohort 1 received EO2463 once every two weeks for a total of four doses followed by once every four weeks for up to 15 doses. After 6 weeks of EO2463 monotherapy oral lenalidomide was added, and if no complete remission was achieved at week 19, rituximab was also included.
Presentation details: About Phase 1/2 SIDNEY About Indolent non-Hodgkin lymphoma (iNHL) About EO2463: The unique ability of EO2463 immunotherapy to selectively target multiple B cell markers enables the destruction of malignant B lymphocytes that are abundant in iNHL. By ensuring broad target coverage across malignant B cells while avoiding a detrimental impact on normal peripheral B cells, this novel approach aims to simultaneously improve safety and maximize efficacy, reducing the tumor cells’ capacity to develop immune escape mechanisms. Contacts
Enterome is a clinical-stage biopharmaceutical company developing breakthrough immunomodulatory drugs for the treatment of cancer and immune diseases. Enterome’s pioneering approach to drug discovery is based on its unique and powerful bacterial Mimicry drug discovery platform, which allows it to analyze and uncover new biological insights from the millions of gut bacterial proteins in constant cross-talk with the human body. Enterome’s first-in-class small protein and peptide drug candidates modulate the immune system by closely mimicking the structure, effect, or actions of specific antigens, hormones, or cytokines. The company is currently developing a pipeline of drug candidates consisting of:
Enterome employs 70 people and is headquartered in Paris, France. Since its inception, the company has raised a total of €118 million from Europe- and US-based life science investors and more than €100 million from pharmaceutical partnerships. For more information, please visit the company’s website at: www.enterome.com |