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Matinas BioPharma's LNC Platform for the Delivery of Small Oligonucleotides Featured in Two Presentations at the ASGCT Annual MeetingBEDMINSTER, N.J., May 07, 2024 (GLOBE NEWSWIRE) -- Matinas BioPharma Holdings, Inc. (NYSE American: MTNB), a clinical-stage biopharmaceutical company focused on delivering groundbreaking therapies using its lipid nanocrystal (LNC) platform delivery technology, announces that James J. Ferguson, M.D., Chief Medical Officer of Matinas, will be presenting two abstracts at the ASGCT 27th Annual Meeting being held May 7-11, 2024 in Baltimore highlighting data from ex vivo, in vitro and in vivo studies evaluating the use of Matinas’ LNC platform for the uptake and targeted delivery of small oligonucleotides. Presentations:
“In the first presentation we report on the dynamics of LNC uptake and cargo delivery ex vivo and in vitro and shows that LNCs – both with and without cargo – are avidly taken up by innate immune cells – like phagocytes – in human blood,” said Dr. Ferguson. “We were also able to dynamically visualize the actual processes of LNC uptake and cargo delivery in cultured cells, with very different dynamics in somatic and cancer cells. These exciting data strongly support our belief that LNCs hold significant future promise for intracellular delivery of complex therapeutics.”
“This second presentation builds on the in vitro work to show that our LNC platform can be used in vivo to orally deliver biologically active – and potentially therapeutic – oligonucleotides designed to target key cytokines in inflammatory disease models,” added Dr. Ferguson. “We are currently focused on optimizing these LNC formulations to improve delivery efficiency, increase potency and extend application of oral cytokine-targeting oligo therapeutics to additional inflammatory disease models.” About the ASGCT Annual Meeting About Matinas BioPharma Matinas’ lead LNC-based therapy is MAT2203, an oral formulation of the broad-spectrum antifungal drug amphotericin B, which although highly potent, can be associated with significant toxicity. Matinas’ LNC platform provides oral delivery of amphotericin B without the significant nephrotoxicity otherwise associated with IV-delivered formulations. Combining comparable fungicidal activity with targeted delivery results in a lower risk of toxicity and potentially creates the ideal antifungal agent for the treatment of invasive fungal infections. MAT2203 was successfully evaluated in the completed Phase 2 EnACT study in HIV patients suffering from cryptococcal meningitis, meeting its primary endpoint and achieving robust survival. MAT2203 will be further evaluated in a single Phase 3 registration trial (the “ORALTO” trial) as an oral step-down monotherapy following treatment with AmBisome® (liposomal amphotericin B) compared with the standard of care in patients with invasive aspergillosis who have limited treatment options. In addition to MAT2203, preclinical and clinical data have demonstrated that this novel technology can potentially provide solutions to many challenges of achieving safe and effective intracellular delivery of both small molecules and larger, more complex molecular cargos including small oligonucleotides such as ASOs and siRNA. The combination of its unique mechanism of action and flexibility with routes of administration (including oral) positions Matinas’ LNC technology to potentially become a preferred next-generation orally available intracellular drug delivery platform. For more information, please visit www.matinasbiopharma.com. Forward-looking Statements Investor Contact |