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Orchard Therapeutics Announces Multiple Presentations at ESGCT 2023Eight presentations highlight the differentiated profile and broad applicability of the company’s HSC gene therapy platform Data from proof-of-concept study of OTL-203 in MPS-IH demonstrate favorable outcomes for clinical manifestations of the disease not well addressed by the current standard-of-care Chief Technical Officer Nicoletta Loggia, Ph.D., to give invited talk on manufacturing strategies and innovations aimed at enabling the application of HSC gene therapy to address more prevalent diseases BOSTON and LONDON, Oct. 24, 2023 (GLOBE NEWSWIRE) -- Orchard Therapeutics (Nasdaq: ORTX), a global gene therapy leader, today announced eight presentations from across its hematopoietic stem cell (HSC) gene therapy platform will be featured at the European Society of Gene and Cell Therapy (ESGCT) 30th Annual Congress taking place October 24-27, 2023, in Brussels. Featured presentations include a range of interim clinical outcomes in addition to the neurological and skeletal results previously reported from the company’s proof-of-concept study of OTL-203 in the Hurler subtype of mucopolysaccharidosis type I (MPS-IH), as well as well as a first look at pre-clinical data demonstrating the use of vectorized HSCs as a delivery vehicle for monoclonal antibodies. In addition, several abstracts from the company’s pre-clinical research programs demonstrate the therapeutic potential of HSC gene therapy to address larger indications, including a genetic sub-type of frontotemporal dementia (FTD) and Crohn’s disease, as well as chronic autoimmune disorders. The company will also host a sponsored symposium on Thursday, October 26, 2023, from 1:30 to 2:50 p.m. CEST featuring expert speakers discussing the potential of HSC gene therapy as a platform to deliver therapeutic genes to target organs such as the brain, bone and GI tract for the treatment of more prevalent diseases where current therapies are limited or do not exist. Additionally, Nicoletta Loggia, Ph.D., chief technical officer, will give an invited talk on Friday, October 27 at 8:30 a.m. CEST, titled “Meeting the moment: Overcoming manufacturing bottlenecks and technical challenges to usher a new era of genetic medicines,” exploring strategies and innovations critical to enabling the application of HSC gene therapy to address larger indications. “Together with our clinical collaborators, we’re proud of our significant presence at ESGCT which continues to underscore the transformative impact and broad applicability of our HSC gene therapy platform,” said Fulvio Mavilio, Ph.D., chief scientific officer of Orchard Therapeutics. “Collectively, these data demonstrate the potential of our approach to correct the underlying genetic defects responsible for several difficult-to-treat diseases, furthering our efforts toward unlocking the full promise of our portfolio.” Details of the oral presentations are follows (all times in CEST):
Details of the poster presentations are as follows (all times in CEST):
About Orchard Therapeutics In 2018, the company acquired GSK’s rare disease gene therapy portfolio, which originated from a pioneering collaboration between GSK and the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy. Today, Orchard is advancing a pipeline spanning pre-clinical, clinical and commercial stage HSC gene therapies designed to address serious diseases where the burden is immense for patients, families and society and current treatment options are limited or do not exist. Orchard has its global headquarters in London and U.S. headquarters in Boston. For more information, please visit www.orchard-tx.com, and follow us on X (Twitter) and LinkedIn. Availability of Other Information About Orchard Forward-looking Statements Other risks and uncertainties faced by Orchard include those identified under the heading "Risk Factors" in Orchard’s most recent annual or quarterly report filed with the U.S. Securities and Exchange Commission (SEC), as well as subsequent filings and reports filed with the SEC. The forward-looking statements contained in this press release reflect Orchard’s views as of the date hereof, and Orchard does not assume and specifically disclaims any obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law. Contact Benjamin Navon +1 857-248-9454 [email protected] |