Apexigen Announces New Phase 2 Data Evaluating Sotigalimab, its CD40 Agonist Antibody, at ASCO Gastrointestinal Cancers Symposium 2023
-Results demonstrate sotigalimab’s ability to turn immunologically “cold” tumors “hot” to increase anti-tumor immune responses for increased therapeutic effect in patients with esophageal/gastro-esophageal junction and rectal cancers-
SAN CARLOS, Calif., Jan. 19, 2023 (GLOBE NEWSWIRE) -- Apexigen, Inc. (NASDAQ: APGN) a clinical-stage company focused on developing innovative antibody-based therapeutics for the treatment of cancer with a focus on immuno-oncology, today announced the presentation of new data from Phase 2 multicenter clinical trials evaluating sotigalimab (sotiga), Apexigen’s agonist antibody targeting CD40, in two poster presentations at the ASCO Gastrointestinal Cancers Symposium, being held both virtually and in San Francisco, California from January 19-21, 2023.
“We are excited to present new data at ASCO demonstrating sotiga’s differentiated mechanism of action and ability to expand anti-tumor immune responses by modulating the tumor microenvironment (TME) for increased therapeutic effect,” said Frank Hsu, M.D., Chief Medical Officer of Apexigen. “In patients with esophageal/gastro-esophageal junction (E/GEJ) cancer, single-agent sotiga turned immunologically “cold” tumors “hot” by inducing significant inflammatory responses in the TME. Following a single dose of sotiga monotherapy there was an increase in T cell density, particularly activated and memory cytotoxic T cells and macrophages. Although patient sample numbers are small, pathologic complete responses were associated with an increased density of T cells following a single dose of sotiga. In a separate study, results demonstrated that adding sotiga to short-course radiation therapy (SCRT) led to increased activation of anti-cancer immune cells, including T cells, B cells and dendritic cells in the TME of rectal cancer patients compared to SCRT alone. We believe sotiga has the potential to provide meaningful clinical benefit across multiple solid tumor indications and become a backbone of combination therapy to address the need for innovative treatment options. We look forward to providing further updates as we advance our clinical program.”
The posters are accessible on-demand through the ASCO Congress portal and additional details are provided below.
Poster (#K16), titled “Use of High-dimensional and Spatial Immune Profiling to Explore Sotigalimab (CD40 Agonist) Activation of Antigen Presenting Cells and T Cells in the Tumor Microenvironment in Patients with Esophageal/Gastroesophageal Junction Cancer,” is being presented by Bridget P. Keenan, M.D., Ph.D., Assistant Professor, Division of Hematology/Oncology, Department of Medicine, at the University of California, San Francisco.
Poster (#K13) titled “Tissue assessment of therapeutic responses to neoadjuvant SCRT with and without anti-CD40 immunotherapy sotigalimab (sotiga) in rectal cancer,” is being presented by Todd Aguilera, M.D., Ph.D., Assistant Professor of Radiation Oncology at UT Southwestern Medical Center.
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