Achilles Therapeutics Announces Grant of US Patent on Immunotherapies Targeting Clonal Neoantigens Identified Using Proprietary Method
LONDON, Nov. 22, 2022 (GLOBE NEWSWIRE) -- Achilles Therapeutics plc (NASDAQ: ACHL), a clinical-stage biopharmaceutical company developing AI-powered precision T cell therapies to treat solid tumors, today announced that United States (US) patent 11,504,398 has been granted. The patent covers the treatment of patients with an immunotherapy targeting clonal neoantigens identified using the Achilles Clonality Engine (ACE), including vaccine, antibody and autologous T cell therapy approaches. ACE is a proprietary method for determining clonality of patient-specific mutations that drives the PELEUS™ bioinformatics platform. Clonal neoantigens are original mutations formed early in tumor evolution that are expressed on all cancer cells and absent from healthy tissue.
“The specific characteristics of clonal neoantigens have led to their emergence as a promising new class of targets for immunotherapies. Historically, identifying these targets has been challenging, given the high genetic complexity of the samples analyzed. With the now-patented ACE method, the PELEUS bioinformatics platform, which is built on the findings of the TRACERx (TRAcking Cancer Evolution through therapy (Rx)) study, rigorously identifies clonal neoantigens from individual patients to serve as targets for precision cancer immunotherapies,” said Dr Sergio Quezada, Chief Scientific Officer of Achilles Therapeutics. “This patent confirms that our data-driven method of identifying personalized clonal mutations is the first of its kind and has potential different modalities including vaccines, antibodies and autologous T cell therapies.”
The patented technology is based on a sophisticated statistical framework to determine the probability that a mutation is clonal through the analysis of a patient’s sequencing data. This novel approach was developed and optimized using clinical data from TRACERx, the largest data set of its kind including genomics from nearly 800 patients. By using this approach immunotherapies can be developed to target these clonal neoantigens, which have been shown to be correlated with responses in patients treated with checkpoint inhibitor therapy1.
About Achilles Therapeutics
This press release contains express or implied forward-looking statements that are based on our management's belief and assumptions and on information currently available to our management. Although we believe that the expectations reflected in these forward-looking statements are reasonable, these statements relate to future events or our future operational or financial performance, and involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance, or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. The forward-looking statements in this press release represent our views as of the date of this press release. We anticipate that subsequent events and developments will cause our views to change. However, while we may elect to update these forward-looking statements at some point in the future, we have no current intention of doing so except to the extent required by applicable law. You should therefore not rely on these forward-looking statements as representing our views as of any date subsequent to the date of this press release.
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