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BGV co-leads €10 million seed investment in neuroscience company FundaMental Pharma
[November 17, 2022]

BGV co-leads €10 million seed investment in neuroscience company FundaMental Pharma

BGV co-leads €10 million seed investment in neuroscience company FundaMental Pharma

Amsterdam, The Netherlands, 17 November 2022 - BioGeneration Ventures (“BGV”), a leading early-stage VC in European biopharma today announces that it has co-led, a €10 million Seed investment in FundaMental Pharma (“FundaMental”), a preclinical neuroscience company spun out of Heidelberg University with Thuja Capital. BGV invested from its Fund IV and following the financing, Dr Keno Gutierrez, Partner at BGV, has been appointed Chair of the Board of FundaMental.

FundaMental is built on the pioneering research of Professor Hilmar Bading and Dr. Jing Yan. This research, published in Science1, identified first-in-class small molecule inhibitors for treatment of a range of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease. FundaMental’s novel approach relies on separating the normal neuroprotective effect of synaptic glutamate from its neurotoxic extra-synaptic actions which are eliminated by the inhibitors.

Dr Keno Gutierrez, Partner at BGV and Chair of FundaMental Board of Directors commented: “FundaMental’s novel therapeutics provide new hope to patients of ALS, Huntington’s disease and spinocerebellar ataxia 3. These remain devastating diseases that have an immense impact on the quality of patients’ lives. We are excited to invest and support the FundaMental team as they endeavour to make these molecules ready for the clinic.”

Dr. Thomas Schulze, CEO and co-founder of FundaMental emphasized: “I am convinced that the successful development of FundaMental’s small molecule inhibitors will mark a milestone in neuropharmacology and possibly beyond. It has been a privilege tohave worked with Professor Bading’s team since 2010 and to have put together such a strong leadership team. Having found visionary investors whose aims are aligned with the founder’s goals of stopping neurodegeneration, this vision can now become reality after many years of dedication and persistence.”

Professor Hilmar Bading, Director of the Department of Neurobiology and the Interdisciplinary Center for Neurosciences at Heidelberg University and Co-Founder of FundaMental added: “It is probably no exaggeration to call the discovery of the new therapeutic principle of ‘inhibition of an extra-synaptic glutamate-activated death signalling complex a breakthrough in neuroscience. These inhibitors have the potential to revolutionize therapies for currently untreatable neurodegenerative diseases, and offer hope to many affected and suffering patients.”

In conjunction with the financing, FundaMental also announced several key senior management appointments and the Board of Directors of the company. Dr. Gabriele Hecker-Barth has joined as Chief Medical Officer and Dr. Jing Yan as Senior Director of Research. Dr. Keno Gutierrez of BGV and Dr. Michel Briejer of Thuja Capital, Professor Hilmar Bading and Dr. Thomas Schulze have been appointed to the company’s Board of Directors.


For more information please contact:

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Laura Asbjornsen, Head of Communications
Email: [email protected]  
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Consilium Strategic Communications
Ashley Tapp, Sue Charles
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Tel: +44 (0)20 3709 5700

About BGV

BioGeneration Ventures (BGV) is a venture capital company, with a focus on early-stage European biotech companies. With a strong track record of significant financial returns through its investments in healthcare innovations and providing the expertise to build world-class companies, BGV manages over EUR 250 million of funds and invests in areas where true scientific innovations, unmet medical needs, and the potential to demonstrate a significant proof of concept all converge. BGV strives to work with founding teams to progress science and build successful companies and uses its experience to guide progress into clinical trials, leading to successful drug development and value realization for its investors. BGV applies its expertise in a rigorous process to select the most compelling opportunities with the best prospects for exit. The Company is based in Naarden, The Netherlands. For more information, please visit:

1 Yan J. et al. Science. 2020 Oct 9;370(6513):eaay3302. doi: 10.1126/science.aay3302.

Jones S. Science (2020).

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