Pliant Therapeutics Presents Preclinical Data Highlighting A Novel Approach for the Treatment of Muscular Dystrophies
- IND submission of a novel a7ß1 integrin activating allosteric antibody anticipated by year end 2022
SOUTH SAN FRANCISCO, Calif., June 22, 2022 (GLOBE NEWSWIRE) -- Pliant Therapeutics, Inc. (Nasdaq: PLRX) presented new preclinical data highlighting the potential of PLN-101325, an a7ß1 integrin activating antibody? for the treatment of muscular dystrophies, including Duchenne Muscular Dystrophy (DMD). These data were presented at the New Directions in Biology and Disease of Skeletal Muscle Conference being held June 20-23, 2022 in Fort Lauderdale, Florida.
The presentation “Increased Laminin Binding Through Integrin Activation Protects Dystrophic Muscle” was presented by Scott Turner, Ph.D., Senior Vice President, Head of Research at Pliant Therapeutics. It highlighted in vitro and in vivo data demonstrating improved cell morphology, tissue organization and muscle function in human cells and D2-MDX mice after treatment with PLN-101325. Importantly, results showed significant improvements in diaphragm muscle strength and respiratory function.
“Our novel approach of employing an allosteric activating antibody to increase laminin adhesion of muscle cells, could reduce the ongoing muscle injury and potentially enhance regeneration in muscular dystrophy patients,” said Dr. Turner. “The increased diaphragm strength and function seen in D2-MDX mice treated with PLN-101325 highlight the potential of this novel therapy to treat a leading cause of death in muscular dystrophy patients."
Progressive loss of muscle mass and strength, including respiratory muscle strength, has been observed in muscular dystrophy, contributing to death from respiratory insufficiency. The a7ß1? integrin is a laminin receptor located on the muscle cell surface that is upregulated in muscular dystrophy patients, serving as a compensatory muscle stabilization mechanism. Activating the a7ß1? integrin may help stabilize the muscle membrane, increase muscle strength, and decrease muscle damage. Because a7ß1? can compensate for the loss of the dystroglycan complex, this mechanism has the potential to be combined with existing therapies, as well as those currently in development.
A copy of this presentation can be found on the Publications page under the Posters & Presentations section of the Pliant website at www.PliantRx.com.
Pliant expects to file an Investigational New Drug (IND) application on this program by the end of 2022, with an anticipated ntry into the clinic in early 2023.
About Pliant Therapeutics, Inc.
Pliant Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel therapies for the treatment of fibrosis. Pliant's lead product candidate, PLN-74809, is an oral small molecule dual selective inhibitor of avß6 and avß1 integrins that is in development in the lead indications for the treatment of idiopathic pulmonary fibrosis, or IPF, and primary sclerosing cholangitis, or PSC. PLN-74809 has received Fast Track Designation and Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) in IPF and Orphan Drug Designation from the FDA and European Medicines Agency in PSC. Pliant is currently conducting Phase 2a trials of PLN-74809 in the lead indications of IPF and PSC. Pliant has also developed PLN-1474, a small molecule selective inhibitor of avß1 for the treatment of nonalcoholic steatohepatitis, or NASH with liver fibrosis, which Pliant has transferred to Novartis pursuant to our development partnership. In addition to clinical stage programs, Pliant currently has two preclinical programs targeting oncology and muscular dystrophies. For additional information about Pliant Therapeutics, visit www.pliantrx.com and follow us on Twitter, LinkedIn, Facebook and YouTube.
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