Akari Therapeutics Presents Results from the CASCADE and CORONET Studies in COVID-19 at the American Thoracic Society (ATS) 2022 Annual Meeting
NEW YORK and LONDON, May 19, 2022 (GLOBE NEWSWIRE) -- Akari Therapeutics, Plc (Nasdaq: AKTX), a late-stage biotechnology company focused on developing advanced therapies for autoimmune and inflammatory diseases, presented results from the CASCADE and CORONET studies in patients with COVID-19 pneumonia at the American Thoracic Society (ATS) 2022 Annual Meeting.
CASCADE, an observational study in a single United Kingdom hospital, explored relationships between circulating biomarkers and risk stratification categories in subsets of COVID-19 pneumonia patients. Patients were clinically stratified as mild, moderate or severe according to degree of respiratory failure on admission and compared to matched healthy controls. Several biomarkers of inflammation, including complement, were elevated across all patient groups compared to healthy controls with complement C5a higher in severe patients compared to moderate patients.
The CORONET study evaluated compassionate use of investigational nomacopan in the treatment of hospitalized COVID-19 pneumonia patients at two centers in the United States. As seen in CASCADE and other studies, the innate immune system plays a potentially important role in driving the pathology of COVID-19 pneumonia. Nomacopan inhibits complement C5a and leukotriene B4 (LTB4). Seven patients were treated with a 45mg subcutaneous dose of nomacopan twice (every 12 hours) on the first day. Subsequently, patients were administered 45mg of subcutaneous nomacopan once daily for 12 days. Prophylactic antibiotics were co-administered with nomacopan. Six patients who received the full course of treatment with nomacopan in the CORONET study survived and were discharged from the hospital. One patient who experienced a delay in the initiation of treatment died. No treatment-related adverse effects were observed.
The posters are available at http://investor.akaritx.com/news-and-events/presentations.
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