argenx Announces Publication of Translational Data of Efgartigimod in Autoimmune Skin Blistering Diseases
Breda, the Netherlands – argenx SE (Euronext & Nasdaq: ARGX), a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases, today announced the publication of novel translational data from the open-label Phase 2 study of efgartigimod for the treatment of pemphigus that further support the potential role of FcRn blockade and potential of efgartigimod in autoimmune skin blistering disorders. The translational data, “FcRn Antagonism Leads to a Decrease of Desmoglein-Specific B Cells: Secondary Analysis of a Phase 2 Study of Efgartigimod in Pemphigus Vulgaris and Pemphigus Foliaceus” were published in the journal Frontiers of Immunology.
The novel translational data, along with previously published translational data in Cells, will also be presented in a symposium today at the Society for Investigative Dermatology (SID) Annual Meeting at 7:30am PT. The complete results from the Phase 2 study of efgartigimod for the treatment of pemphigus were published in the British Journal of Dermatology.
“The publication today highlights the value of our collaborative research model with leading academic centers of excellence, revealing an exciting set of new translational data on the pathophysiology of autoimmune skin blistering diseases and the therapeutic rationale of FcRn blockade in pemphigus and bullous pemphigoid,” said Hans de Haard, Ph.D., Chief Scientific Officer of argenx. “We believe the secondary analysis of our Phase 2 study shows the potential role of FcRn blockade to extend beyond IgG antibody reduction to include an immunomodulatory effect on autoantigen-specific B-cells, which may account for the durable responses observed in the study. We understand the serious unmet need of people living with pemphigus and bullous pemphigoid and are committed to continuing this research on their behalf to bring forward an innovative new treatment option.”
Highlights from Published Translational Data:
Efgartigimod is an antibody fragment designed to reduce pathogenic immunoglobulin G (IgG) antibodies by binding to the neonatal Fc receptor and blocking the IgG recycling process. Efgartigimod is being investigated in several autoimmune diseases known to be mediated by disease-causing IgG antibodies, including neuromuscular disorders, blood disorders, and skin blistering diseases.
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