Acepodia to Present Data from Preclinical and Phase 1 Studies of ACE1702 at the European Society for Medical Oncology (ESMO) 2021 Virtual Congress
ALAMEDA, Calif., Sept. 13, 2021 (GLOBE NEWSWIRE) -- Acepodia, a clinical-stage biotechnology company developing first-in-class cell therapies with its unique Antibody-Cell Conjugation (ACC) platform technology to address gaps in cancer care, today announced that it will present new interim data from an ongoing Phase 1 study (NCT04319757) evaluating ACE1702, the company’s most advanced therapeutic candidate, in patients with advanced HER2 tumors, as an on demand e-Poster at the European Society of Medical Oncology (ESMO) 2021 Annual Congress being held virtually September 16-21, 2021.
Preliminary results from the ongoing clinical trial showed that seven patients treated across the first four dose levels with ACE1702 showed no clinical signs of dose limiting toxicity, such as cytokine release syndrome, neurotoxicity or graft versus host disease. The trial is enrolling patients with advanced HER2-expressing tumors to receive a low dose lymphodepletion (LD) regimen followed by assigned levels of escalating doses of ACE1702 in the range of 0.3-15 billion [B] cells/cycle. Dose escalation is continuing up to 15B cells/cycle with updated clinical data to be provided.
“We are excited to present the initial results from this ongoing study of ACE1702 and our first-in-human trial with an ACC-developed therapeutic candidate,” said Sonny Hsiao, Ph.D., chief executive officer and co-founder of Acepodia. “More than a decade after the foundational discovery of our unique ACC platform technology, this milestone reflects the hard work of our international teams as we continue to gain momentum in the clinical development of our breakthrough investigational off-the-shelf cell therapies.”
The accepted abstract (#1494) is currently available on the ESMO website and can be viewed here. Details of the on-demand e-poster are as follows:
Acepodia’s first-of-its-kind ACC platform technology can link more than 100,000 tumor-targeting antibodies to a variety of different activating and signaling receptors expressed on individual immune effector cells. The ACC platform, combined with Acepodia’s proprietary immune effector cells, increases binding strength against tumors that express low levels of tumor antigens to prevent tumor cell escape. This novel technology enables the company to develop antibody cell effector (ACE) therapies, such as ACE1702, which are potent and targeted, next-generation off-the-shelf cell therapies with the potential to treat a variety of solid tumors and hematologic cancers.
Presentation Details TBA
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