InveniAI Announces Successful Completion of Milestone in its Collaboration with PRISM BioLab Focused on Designing Novel Inflammasome-Targeted Therapeutic Candidates
- Successful generation of INVA8003, a peptidomimetic inhibitor of PYCARD (often referred to as ASC, apoptosis-associated speck-like protein containing CARD) triggers milestone payment to PRISM BioLab
- INVA8003, a first-in-class pan-inflammasome inhibitor, to enter IND enabling studies in 2022
GUILFORD, Conn., July 20, 2021 (GLOBE NEWSWIRE) -- InveniAI® LLC (InveniAI), a global leader in applying artificial intelligence (AI) and machine learning (ML) to transform drug discovery and development, today announced the successful completion of the first milestone in its collaboration with PRISM BioLab Co. Ltd, (PRISM), a biotechnology company with proprietary small-molecule drug discovery technology. This milestone marks completion of the identification and validation of a small molecule drug candidate against PYCARD, also known as ASC (apoptosis-associated speck-like protein containing CARD), an adaptor protein playing a key role in innate immunity and inflammatory response, and identified by InveniAI as a potential target in the treatment of chronic inflammatory and autoimmune gastrointestinal (GI) disorders.
Initiated in September 2020, the collaboration leverages InveniAI's AI-based platform AlphaMeld® with PRISM's proprietary chemistry-platform to expedite the identification of drug candidates efficiently, at scale, and with an enhanced probability of clinical success. The first program to be prioritized for progressing into IND enabling studies is INVA8003, a first-in-class pan-inflammasome inhibitor. A key event in the innate immune response is formation of the inflammasome, a multi-protein complex where PYCARD is a pivotal component. Activation of the inflammasome is implicated in various inflammatory and autoimmune diseases. Inhibition of PYCARD by INVA8003 disrupts the inflammasome assembly, potentially resulting in a strong anti-inflammatory activity across chronic inflammatory and autoimmune disorders that affect the Gut as well as other tissues and organs. Under the terms of the collaboration, PRISM will receive an undisclosed milestone payment from InveniAI.
InveniAI's CSO, Salvatore Alesci, M.D., Ph.D., said, "This important milestone illustrates the continued productivity of our Company's collaboratve culture and discovery efforts across multiple therapeutic modalities. We are encouraged to see our AI-powered pipeline yield novel drug candidates for highly debilitating disorders with great unmet needs, such as Ulcerative Colitis (UC) and Irritable Bowel Syndrome (IBS). Together with our more advanced INVA8001 and INVA8002 programs, INVA8003’s pan-inflammasome activity will enable us to target a broad range of GI and other chronic inflammatory diseases impacted by the gut-brain axis.”
"We are pleased with the rapid completion of the first milestone of our collaboration. The goal of leveraging our combined platforms was to create a paradigm shift in the approach to drug discovery and development. This outcome is a reflection of how the combination of an AI-powered discovery engine and our peptidomimetic technology platform can be readily used to develop small-molecule therapeutics against high impact targets," said Dai Takehara, President, and CEO, PRISM BioLab.
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