TMCnet News
Forbius Announces AVID200, a First-in-Class TGF-beta 1 & 3 Selective Inhibitor, to be Featured at ESMO and CICON 2019Forbius, a clinical-stage protein engineering company that develops biotherapeutics to treat fibrosis and cancer, announces presentations highlighting AVID200's immuno-oncology mode of action at the Fifth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference (CICON) in Paris (Sep. 25 - 28) and European Society of Medical Oncology (ESMO) 2019 Annual Congress in Barcelona (Sep. 27 - Oct. 1). This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20190923005278/en/ Forbius will present at ESMO on Saturday, Sep. 28, at 12:00 PM CEST in Hall 4 (Graphic: Business Wire) The presentations describe the selective targeting of TGF-beta by AVID200 to increase T-cell-mediated cytotoxiciy and immune cell infiltration, resulting in enhanced efficacy of immune checkpoint inhibitors when combined with AVID200 in syngeneic mouse tumor models.
Details of the Presentations Are as Follows:
ESMO
About Forbius: Targeting TGF-beta and EGFR Pathways in Fibrosis and Cancer
Forbius' team of TGF-beta biology experts have designed a proprietary platform of TGF-beta inhibitors with best-in-class potency and selectivity against the principal disease-driving isoforms 1 & 3. This novel class of TGF-beta inhibitors has proven highly active in preclinical models of fibrosis and cancer and was well-tolerated in long-term toxicology studies. Forbius' lead TGF-beta 1 & 3 inhibitor, AVID200, is undergoing Phase 1 clinical trials in two fibrotic indications as well as in solid tumors. Forbius' lead program targeting EGFR is AVID100. AVID100 is an anti-EGFR antibody-drug conjugate (ADC (News - Alert)) with a novel tumor-selective mode of action. This program is undergoing Phase 2a clinical trials in EGFR-overexpressing solid tumors.
About TGF-beta 1 & 3
View source version on businesswire.com: https://www.businesswire.com/news/home/20190923005278/en/ |