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Exicure to Present Data at the American Association for Cancer Research (AACR) 2018 Annual MeetingExicure, Inc., the pioneer in gene regulatory and immunotherapeutic drugs utilizing three-dimensional, spherical nucleic acid (SNA™) constructs, announced today that it will present preclinical data in a poster session at the American Association for Cancer Research (AACR) 2018 Annual Meeting in Chicago, Illinois from April 14-18, 2018. The poster titled "TLR9 agonist SNA-induced innate and adaptive immune responses in tumor microenvironment enhance checkpoint inhibitor antitumor activity in mouse tumor models" supports the ongoing clinical development of the company's proprietary SNA™ technology and highlights its potential impact in the tumor microenvironment in potentiating antitumor effects of anti-PD-1. The data presented in the poster, in combination with many other preclinical studies, provided the basis for advancing Exicure's drug candidate, AST-008, into its Phase 1 clinical trial. We began subject dosing in our Phase 1 clinical trial for AST-008 in the fourth quarter of 2017 and expect this trial to be completed in mid-2018. AST-008 utilizes Exicure's proprietary spherical nucleic acid (SNA) technology designed in this case to agonize toll-like receptor 9, or TLR9, for application in immuno-oncoogy. Exicure has observed that administration of AST-008 as a monotherapy can have anti-tumor activity in colon cancer, breast cancer, lymphoma and melanoma mouse models. The company has also observed that, in preclinical studies in a variety of tumor models, AST-008 applied in combination with certain checkpoint inhibitors exhibited anti-tumor responses and survival rates that were greater than those demonstrated by checkpoint inhibitors alone. Details on the poster presentation are as follows:
Title: TLR9 agonist SNA-induced innate and adaptive immune
responses in tumor micro-environment enhance checkpoint inhibitor
antitumor activity in mouse tumor models Full abstracts are available on the AACR conference website at http://www.aacr.org.
About Exicure, Inc.
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