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Cynata signs Licence Agreement with TekCyte to advance Clinical Trial in Diabetic Foot UlcersMELBOURNE, Australia, June 03, 2021 (GLOBE NEWSWIRE) -- Cynata Therapeutics Limited (ASX: “CYP”, “Cynata”, or the “Company”), a clinical-stage biotechnology company specialising in cell therapeutics, has today announced the execution of a worldwide exclusive licence agreement with TekCyte Pty Ltd (TekCyte) in respect of TekCyte’s wound dressing technology. Cynata has also secured an option to purchase the relevant technology outright. Key highlights
TekCyte has developed proprietary surface modification technologies to produce polymer-coated dressings for the delivery of mesenchymal stem cells (MSCs) to wounds. The licence agreement enables the use of TekCyte’s technologies including in the commercial development of Cynata’s MSC product for diabetic foot ulcers (DFU). Under the license agreement, TekCyte will work with Cynata to manufacture and supply the active dressing for the planned trial. The licence is for the life of the relevant TekCyte patents and involves a signing fee and capped, success-based milestone payments. Cynata’s Cymerus™ MSCs have demonstrated promising efficacy in a preclinical model of diabetic wounds(also known as diabetic ulcers). Those studies, conducted independently by the Cooperative Research Centre for Cell Therapy Manufacturing (CTM-CRC), were designed to compare cells from various sources and utilised TekCyte’s dressing seeded with MSCs or similar cells. Cynata now plans to undertake a clinical trial of its Cymerus MSC product in patients with DFU based on this solid pre-clinical foundation and utilising the TekCyte technology. Dr Kilian Kelly, Cynata’s Chief Operating Officer, said: The encouraging data from the pre-clinical studies provides a strong basis for us to proceed with our Cymerus MSC product utilising TekCyte’s patch technology as a potential treatment. We look forward to finalising trial design and start-up activities and to getting the clinical trial underway.” Authorised for release by Dr Ross Macdonald, Managing Director & CEO CONTACTS: Dr Ross Macdonald, CEO, Cynata Therapeutics, +61 (0)412 119343, [email protected] About Cynata Therapeutics (ASX: CYP) Cynata’s lead product candidate CYP-001 met all clinical endpoints and demonstrated positive safety and efficacy data for the treatment of steroid-resistant acute graft-versus-host disease (GvHD) in a Phase 1 trial. Clinical trials of Cymerus MSC products in osteoarthritis (Phase 3) and in patients with respiratory failure are currently ongoing. Planning is also underway for further clinical trials of Cymerus MSC products in GvHD (through licensee Fujifilm), critical limb ischemia, idiopathic pulmonary fibrosis, renal transplantation, and diabetic foot ulcers. In addition, Cynata has demonstrated utility of its Cymerus MSC technology in preclinical models of numerous diseases, including the clinical targets mentioned above, as well as asthma, heart attack, sepsis, acute respiratory distress syndrome (ARDS) and cytokine release syndrome. 1 Transparency Market Research, 2020 (Reflects global DFU treatment market by 2027). |