Pharvaris Highlights Data Supporting Clinical Development Program for Hereditary Angioedema at the 2022 Bradykinin Symposium
ZUG, Switzerland, Sept. 16, 2022 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a clinical-stage company developing novel, oral bradykinin-B2-receptor antagonists to treat and prevent hereditary angioedema (HAE) attacks, today presented data supporting the development program for PHA121 at the Bradykinin Symposium 2022 in Berlin.
The presentation, titled “Development of PHA121 for On-Demand and Prophylactic Treatment of HAE,” occurred on Friday, September 16, at 10:45 a.m. CEST, and included preclinical and clinical data supporting Pharvaris’ development strategy for two oral therapies for both the on-demand and prophylactic treatment of HAE attacks. The data demonstrate that PHA121, the active ingredient in PHVS416 and PHVS719, is 25-fold more potent than icatibant at inhibiting bradykinin interaction with the endogenous human B2 receptor. Tailored formulations of PHA121 achieved exposure levels predicted from a human bradykinin challenge study to be effective in treating acute HAE attacks and reducing the likelihood of HAE attacks with a convenient single-dose oral administration. The presentation included data supporting the suitability of the pharmacokinetics of PHVS416 for the on-demand treatment of HAE with therapeutic exposure above EC85 within 30 minutes and of PHVS719 daily for the prophylactic treatment of HAE with extended release and absorption from the GI tract providing the necessary therapeutic exposure for more than 24 hours.
“Inhibition of bradykinin signaling via B2-receptor antagonism addresses the fundamental mechanism that leads to HAE symptoms,” said Anne Lesage, Ph.D., Chief Early Development Officer. “The data presented demonstrate that both formulations of PHA121 provide exposures of PHA121 that are predicted to prevent or treat attacks of HAE with profiles tailored to each setting. Pharvaris is uniquely positioned to develop improved HAE therapies due to our deep history in bradykinin-B2-receptor antagonist drug development. The pharmacokinetic data shown for the two oral formulations of PHA121 continue to support the investigation of PHVS416 and PHVS719 for the treatment of HAE.”
A copy of the presentation is available on the Events & Presentations section of the company’s website at https://ir.pharvaris.com/news-events/events-presentations.
These and other important factors could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. While Pharvaris may elect to update such forward-looking statements at some point in the future, Pharvaris disclaims any obligation to do so, even if subsequent events cause its views to change. These forward-looking statements should not be relied upon as representing Pharvaris’ views as of any date subsequent to the date of this press release.