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Horizon Discovery Enters into License Agreement with US Immuno-Oncology CompanyHorizon Discovery Enters into License Agreement with US Immuno-Oncology Company
Under the terms of the agreement, Horizon has licensed to the Partner a novel cell line engineering technology as well as non-exclusive rights to Horizon's proprietary Helitron transposon gene editing technology for an undisclosed financial consideration. The cell line engineering technology will be used to modify a current Horizon biomanufacturing cell line to generate an intermediate, which can easily be further modified through the application of Horizon's proprietary Helitron transposon gene editing technology to introduce specific changes such as the integration of antibody sequences. The intermediate cell line will enable rapid development of a wide range of cell lines designed to produce specific antibodies, enabling more cost effective and efficient antibody manufacture in the future for all the Partner's development programmes. Horizon retains commercial rights to the improved cell line and Helitron transposon technology and will seek additional third-party license agreements for these technologies and others under development to enable cutting edge science and to drive novel workflows that are at the core of our partners' businesses. Dr. Darrin M Disley, Chief Executive Officer, Horizon Discovery, commented: "Innovation and leverage of our capabilities, of which both intermediate cell line engineering and transposon technologies are key examples, are important parts of our strategy as we continue to develop novel ways to address the key challenges facing our customers. This agreement demonstrates the impact of this approach and the value of licenses to our novel technologies, and we anticipate this becoming a significant additional revenue stream for the Group going forward." EDS For further information from Horizon Discovery Group plc, please contact: Horizon Discovery Group plc Consilium Strategic Communications (Financial Media and Investor Relations) Zyme Communications (Trade and Regional Media) Notes for Editors About Horizon's intermediate cell line engineering technology: About Horizon's Helitron transposon gene editing technology: About Horizon's Biomanufacturing platform: Horizon is using its expertise in genome engineering to improve biological therapeutics manufacturing. As well as developing a tool box of cell lines for the manufacture of a range of current and next generation biological therapeutics, Horizon wants to encourage innovation in other organisations by allowing access to its state of the art bioproduction cell line platform (CHO SOURCE) under flexible licensing terms that include allowing the further modification of cells. Glossary:
About Horizon Discovery Group plc www.horizondiscovery.com Horizon Discovery Group plc (LSE: HZD) ("Horizon") is a world leader in gene editing and gene modulation technologies. Horizon designs and engineer's cells using its translational genomics platform, a highly precise and flexible suite of DNA editing tools (rAAV, ZFN, CRISPR and Transposon) and, following the acquisition of Dharmacon, Inc., its functional genomics platform comprising gene knockdown (RNAi) and gene expression (cDNA, ORF) tools, for research and clinical applications that advance human health. Horizon's platforms and capabilities enable researchers to alter almost any gene or modulate its function in human or mammalian cell-lines. Horizon offers an extensive range of catalogue products and related research services to support a greater understanding of the function of genes across all species and the genetic drivers of human disease and the development of personalised molecular, cell and gene therapies. These have been adopted by over 10,000 academic, drug discovery, drug manufacturing and clinical diagnostics customers around the globe, as well as in the Company's own R&D pipeline. Horizon is headquartered in Cambridge, UK, and is listed on the London Stock Exchange's AIM market under the ticker "HZD" |