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Constellation Pharmaceuticals Announces Upcoming Presentations of Lead EZH2 and BET Clinical ProgramsConstellation Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company developing tumor-targeted and immuno-oncology therapies based on its pioneering research and development in cancer epigenetics, today announced scientific and clinical presentations on its most advanced EZH2 and BET (News - Alert) clinical development candidates at three upcoming conferences. Keystone Symposia for Cancer Epigenetics: New Mechanisms, New Therapies
Title: EZH2 inhibitor treatment results in genome-wide EZH2
re-distribution to genes required for terminal differentiation of
germinal center B cells Epigenetics Conference: From Mechanisms to Disease
Title: Utilizing chemical biology to identify novel strategies
targeting histone acetyl signaling in cancer 2018 International Targeted Anticancer Therapies (TAT (News - Alert)) Congress/ESMO
Title: A Phase I Studyof CPI-0610, a Bromodomain and Extra
Terminal Protein (BET) Inhibitor in Patients with Relapsed or Refractory
Lymphoma Session Name: Proffered Paper Session 2 Type: Oral Presentation First Author: Kristie A. Blum Presenter: Adrian Senderowicz Date: March 6, 2018 Time: 11:00 to 11:12 a.m. CET (5:00 to 5:12 a.m. EST) Location: Room Scene AB, Paris Marriott Rive Gauche, Paris, France
Title: A Phase 1 Study of CPI-1205, a Small Molecule Inhibitor of
EZH2, Preliminary Safety in Patients with B-Cell Lymphomas About CPI-1205 CPI-1205 is an experimental small molecule therapy that is designed to inhibit the enzymatic activity of Enhancer of Zeste Homolog 2 (EZH2). The function of EZH2 is to selectively suppress gene expression of several tumor suppressor pathways and pathways that contribute to drug resistance. About CPI-0610 CPI-0610 is an experimental small-molecule therapy designed to inhibit the expression of several genes involved in cancer and fibrosis, including MYC, BCL2, NF-?B and TGF-ß-induced collagen by binding to a family of proteins known as bromodomain and extra-terminal (BET). About Constellation Pharmaceuticals Constellation Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel small-molecule therapies based on its pioneering research in cancer epigenetics. With a decade of experience in the field, the company has an unparalleled understanding of how epigenetic regulators modulate gene expression in cancer cells and in the tumor and immune microenvironment. Constellation is translating these insights to advance the company's two lead clinical programs, CPI-1205 and CPI-0610, and in novel targets for which cancer epigenetics may help overcome resistance mechanisms to currently available treatment options. For more information, please visit www.constellationpharma.com.
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