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Synspira Announces Data for Lead Candidate at the 31st Annual North American Cystic Fibrosis ConferenceSynspira, a privately held company developing a new class of inhaled glycopolymer-based therapeutics for the treatment of pulmonary disease, today announced the presentation of the results of two studies of SNSP113, its lead drug candidate for use in pulmonary complications of cystic fibrosis (CF). The studies were led by the laboratory of Steven M. Rowe M.D. at the University of Alabama at Birmingham and will be presented at the 31st Annual North American Cystic Fibrosis Conference (NACFC), being held from November 2-4, 2017 in Indianapolis, IN. In CF patients, mucus is overproduced, improperly formed and highly viscous, causing thickened airways and compromising pulmonary clearance. Results from one study presented today suggest that SNSP113 has the potential to enhance pulmonary clearance by improving the viscosity and transport of mucins through structure alteration. Studies showed that SNSP113 (active pharmaceutical ingredient is PAAG) improved viscosity and transport of CF sputum on excised rat trachea and altered mucin conformation to resemble a more normal, linear form. In addition, pretreatments of SNSP113 prevented Pseudomonas aeruginosa infection in 70% of wild type rats, whereas all animals treated with control were infected. Enhanced pulmonary clearance is an important aspect of removing bacteria to prevent colonization and infection in the lung. "People living with cystic fibrosis are challenged by abnormal mucus that precipitates chronic infection and dysregulated inflammation," said Dr. Steven M. Rowe, Director of the Gregory Fleming James Cystic Fibrosis Research Center at the University of Alabama, Birmingham. "The effects on both mucus and Pseudomonas bacterial infection demonstrated by SNSP113 are very promising for cystic fibrosis patients, no matter their underlying CFTR mutation." According to the Cystic Fibrosis Foundation (www.CFF.org), there are more than 1,700 mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene; some are common and others are rare and found only in a few people. Certain types of CF mutations are associated with less severe symptoms of the disease, but remain chronic and progressive.
The first study results will be presented at Workshop #8 and Formal
Poter Session I: New Therapies Poster Discussion Session/Workshop. Title: PAAG Alters the Viscoelasticity and Transport of CF Mucus Date: Thursday, November 2, 2017 Time: 9:45 - 11:05 AM EST and 11:15-1:45 PM EST Location: Room 143, Indiana Convention Center and The Exchange - Hall I, Indiana Convention Center A second study demonstrates that SNSP113 could potentially reduce established Pseudomonas infections in CF patients. In studies both as a single agent and in combination with tobramycin, an inhaled antibiotic commonly used in the treatment of lung infections, SNSP113 is shown to reduce the thickness of biofilms and prevent biofilm persistence when grown on CF epithelial cells. These studies demonstrated that PAAG disrupted Pseudomonas aeruginosa biofilms grown in co-culture on CF and wild type respiratory epithelium. Co-treatment with PAAG and tobramycin at the time of inoculation on CF respiratory epithelium augmented tobramycin efficacy against both a laboratory strain, PAO1, and a highly mucoid clinical strain, Pa529. "The results presented today further elucidate how SNSP113 can improve the treatment of cystic fibrosis by potentially reducing chronic infections that impair lung function while also improving the clearance of mucus and bacteria," said Shenda Baker, Ph.D., Chief Executive Officer of Synspira. "We are continuing to evaluate in vivo capabilities of SNSP113 and its safety in a Phase 1a clinical trial as part of our clinical program to advance the treatment of cystic fibrosis patients, regardless of genetic mutation."
The second study results will be presented at a Formal Poster Session.
About SNSP113
About Cystic Fibrosis
About Synspira 1 Cystic Fibrosis Foundation. About Cystic Fibrosis. https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/. View source version on businesswire.com: http://www.businesswire.com/news/home/20171102006093/en/ |