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PKU: Pre-Clinical Kinetic Data Showing Prolonged Release of Amino Acids Thanks to the Innovative Physiomimic Technology by APR Presented at the 13th ICIEM Congress (September 5th-8th, Rio de Janeiro)APR Applied Pharma Research s.a. ("APR"), the Swiss independent developer of science driven and patent protected healthcare products, announces today the results of a pre-clinical kinetic study showing a physiological absorption of clinically relevant groups of amino acids (AAs) thanks to the application of the patented Physiomimic™ drug delivery Technology platform. APR's innovative product is intended to be used for the management of patients with phenylketonuria (PKU). The results of the investigation indicate that the Physiomimic™ Technology by APR is able to modify the release of clinically relevant AAs by lowering and retarding their absorption profiles if compared to the same mix of amino acids without the application of the technology. Also remarkable is that the kinetic profile of the AAs engineered with the Physiomimic™ Technology resembles that of casein - a reference food protein known to have a prolonged absorption profile.
The study suggests that APR's advanced formulation of AAs has the
potential of contributing to maintain Phenylalanine ("PHE") levels
within the recommended ranges, with less prominent fluctuations of
PHE levels over time, thanks to a prolonged release of the AAs in the
gut, which is thought to allow a more efficient utilization of the
absorbed amino acids, PHE included. The outcome of the pre-clinical study will be presented in an oral presentation (Gut Microbiota and Human Metabolism" Thursday September 7th 2017, 11.00-12.30) during the 13th International Congress of Inborn Errors of Metabolism in Rio de Janeiro on September 5 - 8, 2017 (ICIEM 2017). A poster will also illustrate the results of the application of the innovative Physiomimic™ Technology (Attended Poster Session Wednesday September 6th 17:30 - 20:00) to amino acids for PKU. "For the first time, the application of a pharmaceutical drug delivery technology platform to a Medical Food leads to real change in PKU management." Paolo Galfetti, CEO of Applied Pharma Research, states. "Since data show that there are still open issues in the management of PKU, we developed the Physiomimic™ Technology with the aim of meaningfully contributing to fulfill significant unmet needs of this disorder, providing patients, Healthcare Professionals (HCPs) and care givers with a product that would deliver amino acids in a physiological manner, whilst being very palatable and thus significantly improving patient compliance". "The development plan to characterize our innovative product for PKU is robust, - adds Giorgio Reiner, Corporate Director R&D of Applied Pharma Research - "with the next major step being a clinical kinetic study in human volunteers as a proof of concept of the prolonged release of Amino Acids and their consequent physiological absorption. Other pre-clinical studies as well as clinical evidences will reinforce the scientific profile of our proprietary technology and product to help us continue this journey." On October 5th-8th, APR will also sponsor the 31st E.S. PKU Conference (European Society for Phenylketonuria and Allied Disorders Treated as Phenylketonuria), in Hell, Norway continuing to contribute to the advancement of the management of this rare disorder.
About APR Applied Pharma Research s.a.
About Phenylketonuria or PKU
For more information about Physiomimic™ Technology, please visit: www.apr.ch/apr-pharma-products/medical-prescription/genetic-metabolic-disease/
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