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U.S. Patents Awarded to Inventors in Massachusetts (Aug. 22)(Targeted News Service Via Acquire Media NewsEdge) Targeted News Service Targeted News Service ALEXANDRIA, Va., Aug. 22 -- The following federal patents were awarded to inventors in Massachusetts. *** Cytonome/St Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Cytonome/St, Boston, has been assigned a patent (7,997,831) developed by John R. Gilbert, Brookline, Mass., Manish Deshpande, Canton, Mass., and Bernard Bunner, Watertown, Mass., for a "multilayer hydrodynamic sheath flow structure." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip." The patent application was filed on Nov. 2, 2009 (12/610,753). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=79,97,831.PN.&OS=PN/79,97,831&RS=PN/79,97,831 Written by Ruby Maibam; edited by Jaya Anand. *** U.S. National Security Agency Assigned Patent ALEXANDRIA, Va., Aug. 22 -- The U.S. National Security Agency has been assigned a patent (8,001,137) developed by Brian M. Hess, Bolton, Mass., for a "method of identifying connected data in relational database." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method of identifying connected data in relational database by receiving relational database, receiving data components from relational database, initializing a first table and a second table with data identifiers and connection information, initializing a third table with data identifiers, initializing a transition table; replacing each entry in the third table with a user-definable relationship of its corresponding identifier in the second table, its corresponding connected data component identifier in the second table, and the identifier to which an equivalent identifier transitioned in the transition table; updating the transition table, updating the second table, returning to the replacement step if the third table changed, and, otherwise, identifying the received data components as connected that correspond to entries in the third table that are equal." The patent application was filed on Oct. 15, 2009 (12/589,899). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,001,137.PN.&OS=PN/8,001,137&RS=PN/8,001,137 Written by Anjali Jha; edited by Jaya Anand. *** Acushnet Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Acushnet, Fairhaven, Mass., has been assigned a patent (7,998,002) developed by four co-inventors for a "golf ball with negative hardness gradient core." The co-inventors are Michael J. Sullivan, Barrington, R.I., Brian Comeau, Berkley, Mass., Douglas S. Goguen, New Bedford, Mass., and David A. Bulpett, Boston. The abstract of the patent published by the U.S. Patent and Trademark Office states: "A golf ball comprising a single layer core and a cover layer disposed about the single layer core, the single layer core being formed from a substantially homogenous formulation and comprising a geometric center and an outer surface, the single layer core further comprising an inner core region disposed about the geometric center and having a thickness of about 5 mm or lower, an outer core region adjacent the outer core surface and having a thickness of about 5 mm or lower, and an intermediate core region disposed between the inner and outer core regions. The single layer core has a first hardness disposed within the inner core region, a second hardness disposed within the outer core region, and a third hardness disposed within the intermediate core region, wherein the first hardness and second hardness are greater than the third hardness and a hardness of the outer surface is substantially the same as or lower than a hardness of the geometric center." The patent application was filed on May 20, 2009 (12/469,312). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,002.PN.&OS=PN/7,998,002&RS=PN/7,998,002 Written by Anjali Jha; edited by Jaya Anand. *** Lockheed Martin Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Lockheed Martin, Bethesda, Md., has been assigned a patent (7,997,921) developed by four co-inventors for "connecting elements having a stub surrounded by a hollow stalk with a flange." The co-inventors are Walter V. Werner, Pittsford, N.Y., Earl W. Stromberg, Roanoke, Texas, Wit Cezary Bushko, Medway, Mass., and George Hanna Ghanime, Ballston Spa, N.Y. The abstract of the patent published by the U.S. Patent and Trademark Office states: "A plurality of connecting elements projects from a surface of an article. Each connecting element includes a first stalk and second hollow stalk projecting from the surface. The second stalk is generally coaxial with the first stalk and spaced apart from the first stalk defining a radial gap therebetween. The first stalk includes a cap section. The second stalk includes a stem projecting generally orthogonally, at a proximal end thereof, from the surface. A flange section having a first wall thickness extends from a distal end of the stem and has an outer diameter greater than an outer diameter of the stem at the distal end. An engagement section extends from the flange section. A free end of the engagement section having a second wall thickness defines a distal end of the second stalk and has an outer diameter less than the outer diameter of the flange section." The patent application was filed on Oct. 15, 2010 (12/905,665). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7,997,921.PN.&OS=PN/7,997,921&RS=PN/7,997,921 Written by Shabnam Sheikh; edited by Jaya Anand. *** Intrinsic Therapeutics Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Intrinsic Therapeutics, Wobum, Mass., has been assigned a patent (7,998,213) developed by Greg H. Lambrecht, Natick, Mass., Robert Kevin Moore, Natick, Mass., and Jacob Einhorn, Brookline, Mass., for an "intervertebral disc herniation repair." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Systems for minimally invasive disc augmentation include an anulus augmentation component and a nucleus augmentation component. Both are suited for minimally invasive deployment. The nucleus augmentation component restores disc height and/or replaces missing nucleus pulposus. The anulus augmentation component shields weakened regions of the anulus fibrosis and/or resists escape of natural nucleus pulposus and/or the nucleus augmentation component. Methods and deployment devices are also disclosed. Methods of repairing a herniated disc by displacing at least a portion of the herniated segment to within the pre-herniated borders of the disc and anchoring at least a portion of the displaced herniated segment to a site within the disc are also provided." The patent application was filed on Nov. 17, 2006 (11/601,370). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,213.PN.&OS=PN/7,998,213&RS=PN/7,998,213 Written by Arpi Sharma; edited by Jaya Anand. *** Varian Semiconductor Equipment Associates Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Varian Semiconductor Equipment Associates, Gloucester, Ma., has been assigned a patent (7,998,224) developed by Peter L. Kellerman, Essex, Mass., Frederick Carlson, Potsdam, N.Y., and Frank Sinclair, Quincy, Mass., for a "removal of a sheet from a production apparatus." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A melt of a material is cooled and a sheet of the material is formed in the melt. This sheet is transported, cut into at least one segment, and cooled in a cooling chamber. The material may be Si, Si and Ge, Ga, or GaN. The cooling is configured to prevent stress or strain to the segment. In one instance, the cooling chamber has gas cooling." The patent application was filed on Oct. 16, 2009 (12/580,719). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,224.PN.&OS=PN/7,998,224&RS=PN/7,998,224 Written by Arpi Sharma; edited by Jaya Anand. *** Schering Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Schering, Kenilworth, N.J., has been assigned a patent (7,998,961) developed by Umar Faruk Mansoor, Framingham, Mass., Panduranga Adulla P. Reddy, Walpole, Mass., and M. Arshad Siddiqui, Newton, Mass., for a "hydantoin derivatives useful as antibacterial agents." The abstract of the patent published by the U.S. Patent and Trademark Office states: "This invention relates to compounds of the Formula (I): ##STR00001## or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC." The patent application was filed on Aug. 29, 2007 (11/846,804). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,961.PN.&OS=PN/7,998,961&RS=PN/7,998,961 Written by Arpi Sharma; edited by Jaya Anand. *** Abbott Laboratories Assigned Patent for Biosensor Electrode Mediators for Regeneration of Cofactors ALEXANDRIA, Va., Aug. 22 -- Abbott Laboratories, Alameda, Calif., has been assigned a patent (7,998,337) developed by four co-inventors for a "biosensor electrode mediators for regeneration of cofactors." The co-inventors are Nigel J. Forrow, Abingdon, United Kingdom, Gurdial S. Sanghera, Newton, Mass., Jared L. Watkin, Abingdon, United Kingdom, and Stephan Walters, Edgebaston, United Kingdom. The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention is based on the discovery of NAD.sup.+ and NADP.sup.+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes." The patent application was filed on Sept. 30, 2008 (12/242,774). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,337.PN.&OS=PN/7,998,337&RS=PN/7,998,337 Written by Kusum Sangma; edited by Anand Kumar. *** Boston Scientific Scimed Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Boston Scientific Scimed, Maple Grove, Minn., has been assigned a patent (7,998,195) developed by Arthur L. Rosenthal, Wellesley, Mass., for a "device with engineered surface architecture coating for controlled drug release." The abstract of the patent published by the U.S. Patent and Trademark Office states: "In one embodiment of the present invention a coating topology, or engineered surface architecture that may be referred to as a microdroplet deposited engineered surface architecture is provided. A plurality of drops are placed on the stent with the purpose, of building up individual units of coating material on the outer stent surface. This architecture results in a coating that uses less material, i.e., polymer, solvent, medicine, while at the same time providing for better, and determinable, drug kinetics, approaching 100% delivery and better mechanical operation of the coating binding to the stent." The patent application was filed on March 27, 2006 (11/389,712). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,195.PN.&OS=PN/7,998,195&RS=PN/7,998,195 Written by Arpi Sharma; edited by Jaya Anand. *** Kips Bay Medical Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Kips Bay Medical, Minneapolis, has been assigned a patent (7,998,188) developed by nine co-inventors for a "compliant blood vessel graft." The co-inventors are Peter Paul Zilla, Cape Town, South Africa, Nasser Rafiee, Andover, Mass., Deon Bezuidenhout, Cape Town, South Africa, Thomas Franz, Cape Town, South Africa, Mark Yeoman, Forest Row Eash Sussex, United Kingdom, Hellmut Bowles, Bloubergrant, South Africa, Nareak Douk, Lowell, Mass., Michael F. Wolf, Golden Valley, Minn., and Paul Human, Cape Town, South Africa. The abstract of the patent published by the U.S. Patent and Trademark Office states: "Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided." The patent application was filed on May 4, 2007 (11/797,648). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,188.PN.&OS=PN/7,998,188&RS=PN/7,998,188 Written by Arpi Sharma; edited by Jaya Anand. *** Stanford University Assigned Patent for Prevention of Deficits in Neurogenesis with Anti-inflammatory Agents ALEXANDRIA, Va., Aug. 22 -- Leland Stanford Junior University, Palo Alto, Calif., has been assigned a patent (7,998,460) developed by Michelle L. Monje, Boston, and Theo D. Palmer, Stanford, Calif., for a "prevention of deficits in neurogenesis with anti-inflammatory agents." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods are provided for protecting an individual from adverse long-term effects of neuroinflammation. Inflammatory blockade maintains neurogenesis capability after cranial irradiation by reducing the negative effects of activated microglia on neural precursor cells. These findings have broad implications for a variety of diseases of cognition, involving neuroinflammation and precursor cell dysfunction." The patent application was filed on June 21, 2006 (11/473,196). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,460&OS=7,998,460&RS=7,998,460 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Albert Einstein College of Medicine of Yeshiva University, Beth Israel Deaconess Medical Center, Duke University Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Albert Einstein College of Medicine of Yeshiva University, Bronx, N.Y., Beth Israel Deaconess Medical Center, Boston, and Duke University, Durham, N.C., have been assigned a patent (7,998,471) developed by seven co-inventors for a "mycobacteria expressing HIV-1 and malaria antigens." The co-inventors are William R. Jacobs Jr., Pelham, N.Y., Norman L. Letvin, Newton, Mass., Mark Cayabyab, Boston, Barton F. Haynes, Durham, N.C., Hua-Xin Liao, Durham, N.C., Jae-Sung Yu, Durham, N.C., and Avi-Hai Hovav, Brookline, Mass. The abstract of the patent published by the U.S. Patent and Trademark Office states: "Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided are Mycobacterium smegmatis expressing an HIV-1 antigen. Further provided are vaccines capable of inducing an immune response in a mammal against HIV-1 and the malarial pathogen. Additionally provided are methods of inducing an immune response in a mammal against HIV-1 and a malarial pathogen. Also provided are methods of inducing an immune response in a mammal against HIV-1. The methods comprise infecting the mammal with any of the above-described mycobacteria." The patent application was filed on Jan. 11, 2006 (11/794,373). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,471&OS=7,998,471&RS=7,998,471 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Millipore Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Millipore, Billerica, Mass., has been assigned a patent (7,998,349) developed by Kevin Rautio, Manchester-By-The-Sea, Mass., for an "integrity testable multilayered filter device." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to a device having two or more separate filtration layers that can be independently tested for integrity yet which allow for serial filtration through the two or more layers to obtain the desired characteristics such as retention. The device is made of two or more filtration areas, each containing one filter layer. Each area has one filtration layer and a first endcap bonded to a first end of the filter and a second endcap bonded to a second end of the filter. The areas are arranged concentrically around each other such that the first area is inward of the second area which is inward of a third area and the like. Each area is formed separately and integrity tested separately before final assembly. The first area is slid into the inside of the second area and then the two endcaps are either bonded to each, bonded to a third overall endcap or overmolded by a third endcap." The patent application was filed on Sept. 25, 2006 (11/526,476). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,349.PN.&OS=PN/7,998,349&RS=PN/7,998,349 Written by Kusum Sangma; edited by Anand Kumar. *** Elan Pharma International Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Elan Pharma International, Athlone, County Westmeath, Ireland, has been assigned a patent (7,998,507) developed by nine co-inventors for "nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors." The co-inventors are H. William Bosch, Bryn Mawr, Pa., Greta G. Cary, Landsdale, Pa., Douglas C. Hovey, Gilbertsville, Pa., Rajeev A. Jain, Framingham, Mass., Laura J. Kline, Harleysville, Pa., Elaine Merisko-Liversidge, West Chester, Pa., Kevin D. Ostrander, Ringoes, N.J., Niels P. Ryde, Malvern, Pa., and Stephen B. Ruddy, Schwenksville, Pa. The abstract of the patent published by the U.S. Patent and Trademark Office states: "Nanoparticulate compositions comprising at least one poorly soluble MAP kinase inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions." The patent application was filed on Dec. 7, 2005 (11/275,069). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,507&OS=7,998,507&RS=7,998,507 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Cutera Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Cutera, Brisbane, Calif., has been assigned a patent (7,998,181) developed by four co-inventors for a "system and method utilizing guided fluorescence for high intensity applications." The co-inventors are John L. Nightingale, Portola Valley, Calif., Gregory J. Spooner, Kensington, Calif., David A. Gollnick, San Francisco, and Dean A. MacFarland, Magnolia, Mass. The abstract of the patent published by the U.S. Patent and Trademark Office states: "A fluorescence concentrator system that provides for high brightness light source. The system can include a host doped with fluorescent material, which is optically pumped by an adjacent illumination source. The fluorescence concentrator captures a portion of the isotropically emitted fluorescent light and guides it to an output surface. The fluorescent energy emerging the output surface provides a high brightness light source suitable for a number of applications. For example, the fluorescence concentrator system can be used as the light source in a medical apparatus suitable for various aesthetic procedures. Further aspects of the fluorescent concentrator system can include providing for controlling the illumination source to output pumping energy suitable for high energy applications." The patent application was filed on Aug. 15, 2006 (11/504,399). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,181.PN.&OS=PN/7,998,181&RS=PN/7,998,181 Written by Arpi Sharma; edited by Jaya Anand. *** University of Massachusetts Assigned Patent ALEXANDRIA, Va., Aug. 22 -- The University of Massachusetts, Boston, has been assigned a patent (7,998,461) developed by Neil S. Forbes, Belchertown, Mass., and Rachel W. Kasinskas, East Kingston, N.H., for "salmonella cancer therapeutics and related therapeutic methods." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Therapeutic methods for treatment of solid tumor cancer cell masses, as can be effected using therapeutic compositions comprising Salmonella species/strains and related compositions." The patent application was filed on Nov. 17, 2008 (12/313,052). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,461&OS=7,998,461&RS=7,998,461 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Boston Scientific Scimed Assigned Patent for Replenishable Stent and Delivery System ALEXANDRIA, Va., Aug. 22 -- Boston Scientific Scimed, Maple Grove, Minn., has been assigned a patent (7,998,185) developed by James Barry, Marlboro, Mass., for a "replenishable stent and delivery system." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Apparatus and a method for treating an irregularity in a wall of a vessel of a patient defined by an irregular or afflicted wall portion with adjacent normal wall portions comprises a catheter having a distal end portion for being guided through the vessel to the site of the irregularity. A balloon associated with said distal end portion of the catheter for selective inflating to contact the walls of the vessel urges a stent carried by the distal end portion of the catheter in a constricted condition for passage through the vessel into an expanded form with the stent spanning the afflicted wall portion and contacting the adjacent wall portions. The catheter is formed with lumens for inflating the balloon, for receiving a guidewire for guiding the catheter through the vessel, and for connecting a port in the catheter proximate the afflicted wall portion to enable delivery of a therapeutic agent into the vessel to contact the stent and the irregular wall portion." The patent application was filed on July 21, 2005 (11/187,257). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,185.PN.&OS=PN/7,998,185&RS=PN/7,998,185 Written by Arpi Sharma; edited by Jaya Anand. *** Althea Technologies Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Althea Technologies, San Diego, has been assigned a patent (7,998,477) developed by five co-inventors for "spherical protein particles and methods for making and using them." The co-inventors are Kirill Yakovlevsky, Cambridge, Mass., Michael Shamashkin, Somerville, Mass., Nazer Khalaf, Worcester, Mass., Chandrika P. Govardhan, Lexington, Mass., and Chu W. Jung, Arlington, Mass. The abstract of the patent published by the U.S. Patent and Trademark Office states: "This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals." The patent application was filed on Dec. 19, 2003 (10/741,861). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,477&OS=7,998,477&RS=7,998,477 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Massachusetts Inventor Develops Patent for Antimicrobial Material and Method for Making the Same ALEXANDRIA, Va., Aug. 22 -- Michael Szycher, Lynnfield, Mass., has developed a patent (7,998,498) for an "antimicrobial material and method for making the same." The abstract of the patent published by the U.S. Patent and Trademark Office states: "This invention provides a modified catheter biomaterial that provides both immediate, and long-term microbiocidal effects on otherwise antibiotic-resistant strains of microorganisms. The material, which exhibits good mechanical performance characteristics for medical devices, is composed of a hydrophobic polyurethane (PU), a hydrophilic polyethylene vinyl acetate (PEVA), a soluble silver salt and a sparsely-soluble silver salt. The hydrophobic polyurethane provides the good physical properties, the PEVA the hydrophilicity necessary to allow some water ingress into the catheter, the soluble silver salt for an immediate burst effect, and the sparsely-soluble silver salt for sustained-release over many months postimplantation." The patent application was filed on Dec. 31, 2008 (12/347,703). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,498&OS=7,998,498&RS=7,998,498 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Masonite Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Masonite, Tampa, Fla., has been assigned a patent (7,998,382) developed by four co-inventors for a "method of forming a core component." The co-inventors are Geoffrey B. Hardwick, St. Charles, Ill., Henry M. Coghlan, St. Charles, Ill., John Peter Walsh, St. Charles, Ill., and Allen Ray Hill, Laurel, Miss. The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention is directed to a method of forming a molded core component. A mat formed from cellulosic fiber and resin is provided. The mat is consolidated in a first press until the resin is substantially fully cured, and then removed from the first press. The consolidated mat is then placed in a second press having a mold cavity shaped to form at least one depression in at least one of the major surfaces. The consolidated mat is reformed in the second press to form a molded core component having at least one depression in at least one of the major surfaces. The molded core component has a variable density, preferably of between about 10 lbs/ft.sup.3 and 80 lbs/ft.sup.3." The patent application was filed on April 7, 2010 (12/755,670). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,382&OS=7,998,382&RS=7,998,382 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Hyperion Catalysis International Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Hyperion Catalysis International, Cambridge, Mass., has been assigned a patent (7,998,386) developed by Stephen O. Friend, Middletown, Mass., Edward W.S. Bryant, Longmont, Colo., and Harold C. Fowler, Midland, Mich., for a multilayered polymeric structure. The abstract of the patent published by the U.S. Patent and Trademark Office states: "A multilayered polymeric structure having at least two polymeric layers is provided, each layer being a mixture of a polymeric composition with carbon fibrils. The multilayer polymeric structure may include an electrically conductive material between the first and second polymeric layers. A process for making a multilayered polymeric structure for packaging electronic components is also provided. The multilayered polymeric material is used to form trays and packages for containing electrical components." The patent application was filed on Aug. 20, 2007 (11/841,626). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,386&OS=7,998,386&RS=7,998,386 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Tokyo Electron Assigned Patent for Electron Beam Enhanced Surface Wave Plasma Source ALEXANDRIA, Va., Aug. 22 -- Tokyo Electron, Tokyo, has been assigned a patent (7,998,307) developed by Lee Chen, Cedar Creek, Texas, and Paul Moroz, Marblehead, Mass., for an "electron beam enhanced surface wave plasma source." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A plasma processing system is described for generating plasma with a ballistic electron beam using a surface wave plasma (SWP) source, such as a radial line slot antenna (RLSA) during semiconductor device fabrication. The antenna comprises a resonator plate having a partially open, electrically conductive layer coupled to a surface of the resonator plate. For example, the electrically conductive layer is formed at an interface between the resonator plate and the plasma, and a direct current (DC) voltage is applied to the electrically conductive layer." The patent application was filed on Sept. 12, 2006 (11/518,884). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,307.PN.&OS=PN/7,998,307&RS=PN/7,998,307 Written by Kusum Sangma; edited by Anand Kumar. *** Depuy Mitek Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Depuy Mitek, Raynham, Mass., has been assigned a patent (7,998,171) developed by Edwin C. Bartlett, Mansfield, Mass., and Richard F. Wenstrom Jr., Norwood, Mass., for an "apparatus and method for anchoring sutures." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A suture anchor having a conical surface and a bore in which an end of an insertion tool is inserted. The insertion end of the insertion tool is made of material having elastic properties. The bore and base of the suture anchor are angled with respect to the central axis of the suture anchor and preferably are parallel to each other. During insertion, the suture anchor is reoriented to fit into the hole, thereby bending the elastic end of the insertion tool. When the suture anchor is within cancellous bone tissue, the elastic properties of the insertion tool deploys the suture anchor to an orientation in which the suture anchor cannot fit through the bone hole, thereby firmly anchoring the suture anchor in the human bone." The patent application was filed on Aug. 2, 2005 (11/195,576). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,171&OS=7,998,171&RS=7,998,171 Written by Arpi Sharma; edited by Jaya Anand. *** Archemix Assigned Patent for Aptamers that Bind Thrombin with High Affinity ALEXANDRIA, Va., Aug. 22 -- Archemix, Cambridge, Mass., has been assigned a patent (7,998,939) developed by John L. Diener, Cambridge, Mass., Jess Wagner-Whyte, Lynn, Mass., and David Fontana, Clyde Hill, Wash., for "aptamers that bind thrombin with high affinity." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases or disorders in which thrombin has been implicated. The invention further provides materials and methods for the administration of aptamers capable of binding to thrombin." The patent application was filed on Aug. 23, 2006 (11/990,998). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,939.PN.&OS=PN/7,998,939&RS=PN/7,998,939 Written by Arpi Sharma; edited by Jaya Anand. *** Massachusetts Inventor Develops Patent for Rotor Defining a Fluid Separation Chamber of Varying Volume ALEXANDRIA, Va., Aug. 22 -- Jacques Chammas, Walpole, Mass., has developed a patent (7,998,052) for a "rotor defining a fluid separation chamber of varying volume." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A rotor having variable volumes adapted for collecting and centrifuging biological fluids including an impermeable flexible body having a cylindrical shape with stretchable vertical walls and semi pliant base and a rigid circular member seamlessly joined to the top of the flexible body." The patent application was filed on March 7, 2006 (11/368,502). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=79,98,052&OS=79,98,052&RS=79,98,052 Written by Rajat Puri; edited by Jaya Anand. *** pSivida US Assigned Patent ALEXANDRIA, Va., Aug. 22 -- pSivida US, Watertown, Mass., has been assigned a patent (7,998,108) developed by four co-inventors for an "injector apparatus and method of use." The co-inventors are Martin Nazzaro, Quincy, Mass., Hong Guo, Belmont, Mass., Ron LeBlanc, Hopedale, Mass., and Josh York, Ipswich, Mass. The abstract of the patent published by the U.S. Patent and Trademark Office states: "Disclosed herein is an injector device including an inserter element, a head element, an implant and a set of detachable protector elements for secured device handling. The device comprises a stop that controls the penetration depth of the device during injection. The device may comprise a removable catch that prevents the implant from exiting the device due to the advancement of its inserter element. The device may comprise a disengageable block that prevents the implant from exiting the device from its head element. The device may be configured for intraocular drug delivery." The patent application was filed on Sept. 12, 2007 (11/900,907). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=79,98,108&OS=79,98,108&RS=79,98,108 Written by Rajat Puri; edited by Jaya Anand. *** Hyperion Catalysis International Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Hyperion Catalysis International, Cambridge, Mass., has been assigned a patent (7,998,369) developed by four co-inventors for a "polyvinylidene fluoride composites and methods for preparing same." The co-inventors are Chunming Niu, Lexington, Mass., Lein Ngaw, Lowell, Mass., Alan B. Fischer, Cambridge, Mass., and Robert Hoch, Hensonville, N.Y. The abstract of the patent published by the U.S. Patent and Trademark Office states: "An electrically conductive composite comprising a polyvinylidene fluoride polymer or copolymer and carbon nanotubes is provided. Preferably, carbon nanotubes may be present in the range of about 0.5-20% by weight of the composite. The composites are prepared by dissolving the polymer in a first solvent to form a polymer solution and then adding the carbon nanotubes into the solution. The solution is mixed using an energy source such as a sonicator or a Waring blender. A precipitating component is added to precipitate out a composite comprising the polymer and the nanotubes. The composite is isolated by filtering the solution and drying the composite." The patent application was filed on Aug. 20, 2007 (11/841,640). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,369&OS=7,998,369&RS=7,998,369 Written by Satyaban Rath; edited by Hemanta Panigrahi. *** Millennium Pharmaceuticals Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Millennium Pharmaceuticals, Cambridge, Mass., has been assigned a patent (7,998,952) developed by eight co-inventors for "thiolactams and uses thereof." The co-inventors are Indu T. Bharathan, Cambridge, Mass., Matthew Duffey, Boston, Amy Elder, Arlington, Mass., Jianping Guo, Winchester, Mass., Gang Li, Westborough, Mass., Dominic Reynolds, Stoneham, Mass., Francois Soucy, Stoneham, Mass., and Tricia J. Vos, Medford, Mass. The abstract of the patent published by the U.S. Patent and Trademark Office states: "This invention provides compounds of formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are as described in the specification. The compounds are inhibitors of PLK and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders." The patent application was filed on Dec. 4, 2009 (12/631,144). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,952.PN.&OS=PN/7,998,952&RS=PN/7,998,952 Written by Arpi Sharma; edited by Jaya Anand. *** Archemix Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Archemix, Cambridge, Mass., has been assigned a patent (7,998,940) developed by John L. Diener, Cambridge, Mass., H.A. Daniel Lagasse, Somerville, Mass., and Claude Benedict, Cambridge, Mass., for "aptamers to von Willebrand factor and their use as thrombotic disease therapeutics." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor." The patent application was filed on Jan. 29, 2009 (12/322,078). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=7,998,940.PN.&OS=PN/7,998,940&RS=PN/7,998,940 Written by Arpi Sharma; edited by Jaya Anand. *** Sanostec Assigned Patent ALEXANDRIA, Va., Aug. 22 -- Sanostec, Beverly Farms, Mass., has been assigned a patent (7,998,093) developed by Louise S. MacDonald, Beverly, Mass., for an "internal nostril or nasal airway sizing gauge." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods of sizing a nasal airway by using certain measurements of digits may include (a) pressing a distal portion of a digit of a hand against a resilient, flat surface, such that flesh of the distal portion of the digit spreads laterally on the surface; (b) measuring the digit's width at a digit measuring level, the measuring level being the widest part of the digit distal to a distal-most interphalangeal joint of the digit; and (c) identifying a nasal airway size as that size which correlates most closely to the digit's width as measured at the digit measuring level." The patent application was filed on Aug. 25, 2008 (12/197,517). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=79,98,093&OS=79,98,093&RS=79,98,093 Written by Rajat Puri; edited by Jaya Anand. 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