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Researchers from Bioinformatics Institute describe findings in cancer
(Science Letter Via Thomson Dialog NewsEdge)
Research findings, "The p53 knowledgebase: an integrated information resource for p53 research," are discussed in a new report. According to a study from Singapore, Singapore, "The p53 tumor suppressor protein plays a central role in maintaining genomic integrity by occupying a nodal point in the DNA damage control pathway. Here it integrates a wide variety of signals, responding in one of several ways, that is, cell cycle arrest, senescence or programmed cell death (apoptosis)."
"Mutations in the tumor suppressor gene tp53, which affects the key transcriptional regulatory processes in cell growth and death, occur frequently in cancer and helps explain why p53 has been called the guardian of the genome. There is a vast body of published knowledge on all aspects of p53's role in cancer. To facilitate research, it would be helpful if this information could be collected, curated and updated in a format that is easily accessible to the user community. To this end, we initiated the p53 knowledgebase project (http://p53.bii.a-star.edu.sg). The p53 knowledgebase is a user-friendly web portal incorporating visualization and analysis tools that integrates information from the published literature with other manually curated information to facilitate knowledge discovery. This includes curated information on sequence, structural, mutation, polymorphisms, protein-protein interactions, transcription factors, transcriptional targets, antibodies and post-translational modifications that involve p53," wrote Y.P. Lim and colleagues, Bioinformatics Institute.
The researchers concluded: "The goal is to collect and maintain all relevant data on p53 and present it in an easily accessible format that will be useful to researchers in the field."
Lim and colleagues published the results of their research in Oncogene (The p53 knowledgebase: an integrated information resource for p53 research. Oncogene, 2007;26(11):1517-21).
For additional information, contact Y.P. Lim, Bioinformatics Institute, Matrix, Singapore, Singapore.
The publisher of the journal Oncogene can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St., London N1 9XW, England.
Keywords: Singapore, Singapore, BioInformatics LLC, Bioinformatics, Biotechnology Business, Biotechnology Company, Cancer, Oncology, Tumor Suppression.
This article was prepared by Science Letter editors from staff and other reports. Copyright 2007, Science Letter via NewsRx.com.
Copyright 2007 Science Letter via NewsRx.com
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