[February 02, 2006] Chinese typhoid vaccine appears effective Tweet (Science Letter Via Thomson Dialog NewsEdge) Results from six years of follow-up indicate that a locally produced, Chinese Vi polysaccharide typhoid fever vaccine is efficacious. Scientists in South Korea and China report, "A locally produced Vi polysaccharide vaccine against typhoid fever was licensed in China following two placebo-controlled, efficacy trials conducted in the early 1990s in Baoying, Jiangsu Province, and Quan-zhou. Guangxi Province. The two trials each enrolled over 80,000 participants and followed participants for 12 and 19 months post-vaccination. respectively. To define the long-term efficacy of this vaccine, we retrospectively assessed the occurrence of typhoid fever diagnosed with clinical and serological criteria in the two study populations for six years following vaccination." "During the second year following vaccination, vaccine efficacy was 100% 95% CI: 17% 100%) in Baoying and 85% (95% CI: 49%, 96%) in Quan-zhou," stated Camilo J. Acosta at the International Vaccine Institute in Seoul and collaborators in South Korea and China. "There was suggestive protection (51% PE: -95%, 88%) during the third year in Baoying, nearly identical to the level observed in the third year of an earlier trial in South Africa." "These results confirm that this vaccine protects for at least two years, and are consistent with the assertion that the vaccine protects for at least three years," the authors noted. Acosta and associates published their study in Vaccine (Efficacy of a locally produced, Chinese Vi polysaccharide typhoid fever vaccine during six years of follow-up. Vaccine, 2005;23(48-49):5618-5623). For additional information, contact Camilo J. Acosta, 167 Ladderback Lane, Devon, PA 19333, USA. E-mail: [email protected]. The publisher's contact information for the journal Vaccine is: Elsevier Science Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. Keywords: Seoul, South Korea, Typhoid Vaccine, Vaccine Development, Vaccine Efficacy, Typhoid Fever, Immunology, Immunotherapy. This article was prepared by Science Letter editors from staff and other reports. Copyright 2006, Science Letter via NewsRx.com. [ Back To TMCnet.com's Homepage ]