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Tripos Names Dr. Tom Mander as Vice President of Business Development and Strategic Alliances, Discovery Research
[December 15, 2005]

Tripos Names Dr. Tom Mander as Vice President of Business Development and Strategic Alliances, Discovery Research


ST. LOUIS, & BUDE, England --(Business Wire)-- Dec. 15, 2005 -- Tripos, Inc. (Nasdaq:TRPS), a leading provider of drug discovery chemistry and informatics products and services, today announced that it has appointed Dr. Tom Mander as vice president of business development and strategic alliances, Discovery Research. In his new role, Mander will be responsible for identifying new business development opportunities, establishing strategic alliances, developing intellectual property, and driving marketing initiatives for Tripos Discovery Research, Ltd. (TDR), which is located in Bude, England.

"Tom possesses an ideal blend of scientific expertise, leadership skills and international business development experience that will contribute to TDR's continued evolution," said Dr. Mark Allen, senior vice president and managing director of TDR.

Mander brings more than 13 years of experience in small molecule drug discovery to Tripos. For the past six and a half years, Mander has held a variety of operational and commercial roles at Evotec, including department manager, product manager and vice president of business development. He is credited with pioneering Evotec's biological service offerings, launching several new products lines including Compound Management, establishing new strategic partnerships, and creating new business models. Before joining Evotec, Mander was a group leader at Glaxo Wellcome, and held senior scientific roles at Xenova Ltd., the Centre for Natural Product Research (now MerLion) and Amersham International (now GE Healthcare).


"I am delighted to have joined Tripos Discovery Research," Mander said. "It has established an unsurpassed level of expertise in high throughput parallel and analytical chemistry in a truly unique location conducive to innovation and creativity on behalf of its partners. I am looking forward to utilizing my experience to drive the company forward as we begin a new era at Tripos."

Mander holds a Doctor of Philosophy degree in a study of the physiological roles of microglia (brain macrophages) from the University of Oxford, a master of business administration degree from the Open University, and a bachelor's degree in medical biochemistry from the School of Biological Sciences at the University of Surrey.

General

This press release contains forward-looking statements concerning expectations regarding Dr. Mander's managerial responsibilities and value to Tripos. These statements are based upon numerous assumptions which Tripos cannot control and involve risks and uncertainties that could cause actual results to differ. These statements should be understood in light of the risk factors set forth in the Company's filings with the Securities and Exchange Commission, including, without limitations, those factors set forth in the Company's Form 10-K for the fiscal year ended December 31, 2004, and from time to time in the Company's periodic filings with the Securities and Exchange Commission. Except as otherwise required under federal securities laws and the rules and regulations of the SEC, we do not have any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events, changes in assumptions or otherwise.

About Tripos, Inc.

Tripos (Nasdaq:TRPS) combines leading-edge technology and innovative science to deliver consistently superior chemistry-research products and services for the biotechnology, pharmaceutical and other life science industries. Within Tripos' Discovery Informatics (DI) business, the company provides software products and consulting services to develop, manage, analyze and share critical drug discovery information. Within Tripos' Discovery Research (DR) business, Tripos' medicinal chemists and research scientists partner directly with clients in their research initiatives, leveraging state-of-the-art information technologies and research facilities. Further information on Tripos can be found at http://www.tripos.com.

Tripos and the Tripos logo are registered trademarks of Tripos, Inc., and/or its affiliates in the United States and certain other countries. All other trademarks mentioned in this document are the property of their respective owners.

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