[September 17, 2014]

Ignyta to Participate in Precision Medicine Panel Discussions with Other Thought Leaders

Ignyta, Inc. (Nasdaq: RXDX), an oncology precision medicine biotechnology company, today announced that its Chairman and CEO, Jonathan Lim, M.D., has been invited to participate in upcoming panel discussions relating to innovation in Rx/Dx strategies and novel science developments in precision medicine.

Dr. Lim will participate in a panel discussion on the topic of "Novel Science Developments: Precision Medicine," moderated by Bill Rastetter, Ph.D., Former Executive Chairman of Biogen Idec and Former Chairman and CEO of Idec Pharma, at the Leerink Healthcare Leadership Summit on September 18, 2014 in Napa, California.

Dr. Lim will also be part of a panel discussion at the Cancer Advance Conference at Harvard Medical School on September 30, 2014 on the topic of "Next Generation -Omics Technologies: Innovation in Rx/Dx Strategies," moderated by Raju Kucherlapati, Ph.D., the Paul C. Cabot Professor in the Harvard Medical School Department of Genetics.

"Ignyta desires to be a guiding biotechnology company in precision medicine for the benefit of cancer patients," said Dr. Lim. "It is an honor to be able to exchange ideas and key learnings with our peers so we can collectively optimize patient care with novel Rx/Dx approaches."

About Ignyta, Inc.

Ignyta, Inc., located in San Diego, California, is a biotechnology company developing precision medicine with integrated Rx/Dx solutions for cancer patients. The company's goal is to discover and develop revolutionary new drugs that target activated genes in cancer cells for the customized treatment of cancer patients. Ignyta's present focus is on the developent of RXDX-101, its proprietary oral tyrosine kinase inhibitor that targets multiple solid tumor indications, the development of its newly-licensed RXDX-103 and RXDX-104 kinase inhibitors, and advancing its novel Spark discovery programs that leverage its proprietary cancer genomic and epigenomic knowledge bases. For more information, please visit: www.ignyta.com.

Forward-Looking Statements

This press release contains forward-looking statements about Ignyta as that term is defined in Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, references to the Dr. Lim's participation in upcoming panel discussions and the potential to optimize patient care with novel Rx/Dx approaches. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, the inherent uncertainties associated with developing new products or technologies and operating as a development stage company; Ignyta's ability to develop, complete preclinical studies and clinical trials for, obtain approvals for and commercialize any of its product candidates; changes in Ignyta's plans to develop and commercialize its product candidates; the potential for final results of ongoing Phase I/II clinical trials of RXDX-101, or any future clinical trials, to differ from preliminary results; regulatory developments in the United States and foreign countries; Ignyta's ability to raise any additional funding it will need to continue to pursue its business and product development plans; Ignyta's ability to obtain and maintain intellectual property protection for its product candidates, including reliance on its licensor Nerviano for the prosecution and maintenance of certain key intellectual property for all of Ignyta's in-licensed product candidates; the loss of key scientific or management personnel; competition in the industry in which Ignyta operates; and market conditions. These forward-looking statements are made as of the date of this press release, and Ignyta assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents the company files with the SEC (News - Alert) available at www.sec.gov, including without limitation Ignyta's Annual Report on Form 10-K for the year ended December 31, 2013 and subsequent Quarterly Reports on Form 10-Q.

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