[February 23, 2006] Caveolin-1 expression in pleomorphic carcinoma correlated with poor prognosis Tweet (Science Letter Via Thomson Dialog NewsEdge) Caveolin-1 expression in pleomorphic carcinoma of the lung was associated with a poor prognosis. According to a study from South Korea, "Caveolin-l is implicated in the oncogenic transformation of cells as a tumor suppressor in several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL). Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression." "Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression," explained K.C. Moon and colleagues, Seoul National University. The researchers concluded, "However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size. These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is marker for predicting prognosis in PCL." Moon and colleagues published their study in Anticancer Research (Expression of caveolin-1 in pleomorphic carcinoma of the lung is correlated with a poor prognosis. Anticancer Res, 2005;25(6C):4631-4637). For more information, contact D.H. Chung, Seoul National University, College Med, Dept. Pathology, 28 Chongnogu, Seoul 110799, South Korea. Publisher contact information for the journal Anticancer Research is: International Institute Anticancer Research, Editorial Office 1st km Kapandritiou-Kalamou Rd. Kapandriti, PO Box 22, Athens 19014, Greece. Keywords: Seoul, South Korea, Lung Cancer, Lung Carcinoma, Oncology, Pleomorphic Cancer, Pleomorphic Carcinoma, Prognosis, Prognostics, Cancer Therapy, Tumor Suppression, Tumors, Caveolin-1. This article was prepared by Science Letter editors from staff and other reports. Copyright 2006, Science Letter via NewsRx.com. [ Back To TMCnet.com's Homepage ]