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Medigene, IRICoR and Université de Montréal Sign Collaboration and Exclusive Licensing Option on Novel Cancer AntigensMARTINSRIED, Germany and MUNICH, Germany and MONTRÉAL, Jan. 29, 2020 (GLOBE NEWSWIRE) -- Medigene AG (Medigene, FSE: MDG1, Prime Standard), a clinical-stage immuno-oncology company focusing on the development of T cell immunotherapies, announces today that it has entered into a research collaboration on novel cancer antigens for highly specific immunotherapies with the Université de Montréal (UdeM) and IRICoR, a pan-Canadian drug discovery research commercialization center. UdeM’s research team, led by Drs. Claude Perreault and Pierre Thibault at the Institute for Research in Immunology and Cancer (IRIC), will provide Medigene with tumor-specific antigens (TSAs) which they discovered using their proprietary platform, as novel targets for various cancer indications, particularly for solid tumors. Under the terms of the agreement, Medigene will evaluate a number of proprietary TSA targets provided by UdeM through IRICoR, and will receive an option to exercise an exclusive and worldwide license to develop and commercialize T cell receptors (TCRs) against up to 5 of these novel cancer antigens. Upfront and near-term payments by Medigene to UdeM and IRICoR could potentially reach mid to high single-digit millions over the course of the next five years. Additionally, UdeM and IRICoR are eligible to receive development, regulatory and commercial milestone payments, along with tiered royalties, on a per target basis. Prof. Dolores Schendel, CEO and CSO of Medigene AG: "The goal of immunotherapies is to fight cancer using the immune system. Medigene’s TCR-based therapies aim to modify the patient's own T cells so they can specifically recognize and eliminate tumor cells. It is essential that the immune system differentiates precisely between cancer cells and healthy tissue. The research work from UdeM on tumor antigens is fascinating and offers a broad and complementary development opportunity for Medigene’s TCR therapies. These TSAs are uniquely found in tumor cells but are not present in healthy tissue, and are therefore particularly interesting as targets for tailor-made immunotherapies. We believe that this cooperation could expand our portfolio with promising, novel targets that are solely expressed in cancer cells.” Dr. Nadine Beauger, Chief Executive Officer of IRICoR: “IRICoR is delighted to be a part of this new partnership. The foundational funding provided by IRICoR to develop this unique proteogenomic approach led to the unprecedented discovery of human TSAs coded by potentially all genomic regions using high-throughput mass spectrometry. These newly-discovered targets open countless avenues for more targeted cancer treatments for the benefit of patients worldwide.” Dr. Steven Klein, Vice-President, Business Development of IRICoR added: “IRICoR has a strong track record of collaborating with international partners such as Medigene and negotiating the necessary agreements to ensure that these relationships are successful in transforming innovative technologies, such as the TSA platform, into new therapies.” Michel Bouvier, Chief Executive Officer and Principal Investigator, IRIC; Professor, Department of Biochemistry and Molecular Medicine, Université de Montréal: “UdeM and its researchers at IRIC are at the forefront of developing novel therapies for cancers with high unmet medical need. The exciting research of Drs. Perreault and Thibault is a concrete example of how world-class fundamental research carried out at IRIC can be translated into potential new therapies through the financial and business support of IRICoR. We look forward to a very fruitful collaboration between UdeM, IRICoR, and Medigene and to seeing these new T cell-based therapies reach patients who are in need o new therapeutic options.” About UdeM/IRICoR TSAs Reference: About IRICoR For more information about IRICoR: www.iricor.ca About the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal For more information: www.iric.ca About Medigene The Company is developing highly innovative immunotherapies to target various forms and stages of cancer. Medigene concentrates on the development of personalized T cell-based therapies, with associated projects currently in pre-clinical and clinical development. Read more about Medigene’s company profile: https://www.medigene.com Other news: This press release contains forward-looking statements representing the opinion of Medigene as of the date of this release. The actual results achieved by Medigene may differ significantly from the forward-looking statements made herein. Medigene is not bound to update any of these forward-looking statements. Medigene® is a registered trademark of Medigene AG. This trademark may be owned or licensed in select locations only. Contact Medigene Contact IRICoR Contact IRIC In case you no longer wish to receive any information about Medigene, please inform us by e-mail ([email protected]). We will then delete your address from our distribution list.
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