CervoMed Publishes Positive Results from AscenD-LB Phase 2a Trial in Peer-Reviewed Journal that Supports the Therapeutic Potential of Neflamapimod in Dementia with Lewy Bodies
-Integrated summary of all previously published Phase 2a clinical results, together with the first peer reviewed publication of EEG and MRI results, substantially derisk the ongoing RewinD-LB Phase 2b trial of neflamapimod in dementia with Lewy bodies -
-RewinD-LB trial remains on track to complete enrollment in the first half of 2024 and report primary efficacy results in the second half of 2024-
BOSTON, Feb. 12, 2024 (GLOBE NEWSWIRE) -- CervoMed Inc. (NASDAQ: CRVO), a clinical stage company focused on developing treatments for degenerative diseases of the brain, announced that data from the AscenD-LB Phase 2a trial evaluating treatment with neflamapimod in patients with dementia with Lewy bodies (DLB) were published online in the Journal of Prevention of Alzheimer’s Disease (JPAD). The published manuscript titled “Phase 2a learnings incorporated into RewinD-LB, a Phase 2b clinical trial of neflamapimod in dementia with Lewy bodies,” is available online.
“The publication of the EEG and MRI results round out the Phase 2a data that supports the advancement of neflamapimod into late-stage development as a treatment for DLB,” said John Alam, MD, Chief Executive Officer of CervoMed. “While there are currently no approved treatment options for patients with DLB, we are encouraged by the positive data generated to date and look forward to building on the Phase 2a results with our ongoing RewinD-LB Phase 2b trial, which is expected to provide a clear path to market in this high value indication. Our RewinD-LB trial, which we believe is derisked through the incorporation of learnings outlined in the publication, is highly powered and designed to stratify patients most likely to benefit from neflamapimod. RewinD-LB remains on track to complete enrollment in the first half of 2024 and we expect to report primary efficacy results in the second half of 2024.”
Results published for the first time in the JPAD manuscript are as follows:
Table: AscenD-LB Results in Neflamapimod 40mg TID, in Overall Patient Population and in Pure DLB Patients
Key learnings from AscenD-LB have been incorporated into the ongoing RewinD-LB Phase 2b trial of neflamapimod, including the use of a single dose regimen of neflamapimod 40mg TID, enrolling patients with pure DLB and selecting CDR-SB as the primary endpoint. To further evaluate potential effects on the underlying disease process, structural and functional MRI will be evaluated in a 40-patient subgroup to assess treatment effects on atrophy of the basal forebrain, as well its functional connectivity.
About the RewinD-LB Phase 2b Study in Dementia with Lewy Bodies