Myriad Genetics and Leading Cancer Center Collaborate to Study the Use of Minimal Residual Disease Testing in Breast Cancer
SALT LAKE CITY, Sept. 18, 2023 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc., (NASDAQ: MYGN), a leader in genetic testing and precision medicine, today announced a collaboration with Memorial Sloan Kettering Cancer Center (MSK) to study the use of minimal residual disease (MRD) testing in breast cancer. The research project will use Myriad’s MRD testing platform, a tumor-informed high-definition assay that uses whole-genome sequencing to achieve high sensitivity and specificity for circulating tumor DNA (ctDNA).
Myriad is working together with Pedram Razavi, MD, PhD, a breast medical oncologist and Director of Liquid Biopsy & Genomics at MSK Global Biomarker Development Program. The MSK research team will investigate the use of MRD testing for patients in two breast cancer cohorts. The first will be in a metastatic patient population treated with CDK4/6 inhibitors and will evaluate the ability of MRD testing to predict treatment response. The second will be focused on the neoadjuvant setting and will assess the association of MRD testing with chemotherapy treatment response.
“Several publications show that MRD testing provides prognostic information about cancer recurrence, but the studies we are undertaking with MSK will be among the first few to assess the predictive benefit of MRD testing associated with particular treatments,” said Dale Muzzey, chief scientific officer, Myriad Genetics. “Because we use whole-genome sequencing to inform our MRD assay, we often have thousands of tumor-specific sites to track rather than the tens of sites available in other MRD assays. The increased number of sites is particularly important in breast cancer, which tends to have low tumor fraction, so having more sites is critical to detecting low-level cancer with confidence.”
“This collaboration could elp to transform treatment for patients with metastatic breast cancer by better determining who will respond to a therapy and who will not,” said Dr. Razavi. “We anticipate the MRD test from Myriad will be more sensitive and specific than many other ctDNA offerings for monitoring the response and, therefore, may more accurately identify the patients who will or will not benefit from certain therapies. Importantly, some of these patients may go undetected on a less-sensitive MRD test. We are further excited by the prospect of using a combined tumor tissue and ctDNA approach to predict and detect when and how tumors acquire resistance, such that the therapeutic regimen can adapt accordingly.”
Myriad’s MRD test is available for use in research studies pursued jointly by Myriad and academic or pharmaceutical investigators. It can be used to monitor ctDNA levels throughout a cancer patient’s clinical care, starting immediately after diagnosis and continuing through survivorship monitoring.
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