EyePoint Pharmaceuticals Announces Upcoming Data Presentations at 2023 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
- Positive neuroprotective effect of vorolanib, the active drug in EYP-1901, in a widely validated retinal detachment model demonstrates a potential new mechanism of action for the treatment of retinal disease -
- Clinical outcomes from real-world CALM registry study of YUTIQ® demonstrates effective control of inflammation in chronic posterior segment uveitis -
WATERTOWN, Mass., March 20, 2023 (GLOBE NEWSWIRE) -- EyePoint Pharmaceuticals, Inc. (NASDAQ: EYPT), a company committed to developing and commercializing therapeutics to improve the lives of patients with serious eye disorders, today announced multiple scientific presentations at the 2023 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, being held April 23 – 27 in New Orleans, Louisiana.
“We are excited to be presenting these positive data in support of EYP-1901 and YUTIQ at this year’s ARVO Annual Meeting,” said Jay Duker, M.D., President and Chief Operating Officer of EyePoint Pharmaceuticals. “We are particularly enthusiastic about the compelling preclinical data that highlights the potential neuroprotective effect of vorolanib, the active drug in EYP-1901, against photoreceptor degeneration in a validated retinal detachment model. These preclinical data on vorolanib bring an additional perspective to our positive Phase 1 DAVIO 12-month results, which will be showcased in an encore presentation at the meeting.”
Dr. Duker added, “The preclinical data derived from a widely validated model of retinal detachment highlights vorolanib’s potential new mechanism of action for treating retinal diseases, and its unique benefits that set it apart from existing ligand binding biologics.” “These preclinical data demonstrate that vorolanib significantly reduced the severity of change in baseline visual acuity and improved contrast thresholds in mice treated with vorolanib compared with placebo, suggesting a neuroprotective effect against photoreceptor degeneration. Should this be reflected in clinical data, it would provide an important new mechanism of action for the treatment of these chronic, blinding retinal eye diseases such as wet AMD, diabetic retinopathy, diabetic macular edema and retinal vein occlusion. In addition, we will present important registry study data that demonstrates YUTIQ’s effective control of inflammation in real-world patients living with chronic posterior segment uveitis.”
Presentation details are as follows:
Presentation Title: Neuroprotective Effect of Tyrosine Kinase Inhibitor Vorolanib in a Mouse Model of Retinal Detachment
Presentation Title: The DAVIO Trial: A Phase 1, Open-Label, Dose-Escalation Study of a Single Injection of EYP-1901 (Vorolanib in Durasert® Platform) Demonstrating Reduced Treatment Burden in Wet Age-Related Macular Degeneration
Presentation Title: CALM: 12-month Results from a Real-World Registry to Characterize Clinical Outcomes for Patients with Chronic on-Infectious Posterior Segment Uveitis Treated with a 0.18 Mg Fluocinolone Acetonide Intravitreal Insert
Date and Time: Thursday, April 27, 2023 from 10:30 a.m. to 12:15 p.m. CT / 11:30 a.m. to 1:15 p.m. ET
Presenter: Stephen Anesi, M.D., Partner at Massachusetts Eye Research and Surgery Institution
Presentation Type/Number: Paper Session #5097
Presentation Title: CALM: A Retrospective Registry to Characterize Clinical Outcomes for Chronic Non-Infectious Posterior Segment Uveitis Patients Treated with the 0.18 Mg Fluocinolone Acetonide Intravitreal insert: Intraocular Pressure and Safety Data Analysis
Presentation Title: CALM: A Retrospective Registry to Characterize Clinical Outcomes for Chronic Non-Infectious Posterior Segment Uveitis Patients Treated with the 0.18 Mg Fluocinolone Acetonide Intravitreal Implant: Retinal Anatomical Outcomes
The abstracts are now available online on the 2023 ARVO Annual Meeting conference website at https://www.arvo.org/annual-meeting/.
EYP-1901 is being developed as an investigational sustained delivery treatment combining a bioerodible formulation of EyePoint's proprietary Durasert® delivery technology with vorolanib, a tyrosine kinase inhibitor. Positive safety and efficacy data from the DAVIO Phase 1 clinical trial of EYP-1901 showed no reports of ocular or drug-related systemic serious adverse events and no dose limiting toxicities with stable visual acuity and OCT. Further, 53% and 35% of eyes did not require any supplemental anti-VEGF injections up to six and twelve months, respectively, following a single dose of EYP-1901. Phase 2 studies are underway for wet AMD and non-proliferative diabetic retinopathy and are planned for diabetic macular edema in 2023. Vorolanib is licensed to EyePoint exclusively by Equinox Sciences for the localized treatment of all ophthalmic diseases.
About EyePoint Pharmaceuticals
EyePoint Pharmaceuticals (Nasdaq: EYPT) is a company committed to developing and commercializing therapeutics to help improve the lives of patients with serious eye disorders. The Company's pipeline leverages its proprietary Durasert® technology for sustained intraocular drug delivery including EYP-1901, an investigational sustained delivery intravitreal anti-VEGF treatment currently in Phase 2 clinical trials. The proven Durasert drug delivery platform has been safely administered to thousands of patients' eyes across four U.S. FDA approved products, including YUTIQ® for the treatment of posterior segment uveitis, which is currently marketed by the Company. EyePoint Pharmaceuticals is headquartered in Watertown, Massachusetts.
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