AltruBio Announces First Patient Dosed in Phase 1 Trial of Next-Generation Immune Checkpoint Enhancer ALTB-268 for the Treatment of Ulcerative Colitis
SAN FRANCISCO, Jan. 23, 2023 (GLOBE NEWSWIRE) -- AltruBio Inc. (“AltruBio” or “the Company”), a clinical stage biotech company dedicated to the development of novel therapeutics for the treatment of immunological diseases with high unmet medical needs, today announced that it has dosed the first patient in a Phase 1 study evaluating ALTB-268, its next-generation PSGL-1 antibody agonist serving as an immune checkpoint enhancer (ICE), in healthy volunteers.
“The dosing of the first patient in this Phase 1 clinical trial represents a major milestone for AltruBio, and we look forward to executing on the clinical potential of ALTB-268, our next-generation, subcutaneously administered ICE,” said Judy Chou, Ph.D., President and Chief Executive Officer of AltruBio. “We are thrilled to bring ALTB-268 into the clinic to evaluate its safety and tolerability as a first step towards providing not only a more conveniently administered but potentially more durable and effective treatment option for patients suffering from immunological diseases including ulcerative colitis. The Phase 1 study was built on the clinically validated mechanism of action and strong preclinical data which showcased the improved potency in eliminating pathogenic chronic T cells. We believe ALTB-268 can realize the ‘pipeline-in-a-product’ potential for multiple autoimmune and inflammatory diseases in a patient population with high unmet medical needs.”
The Phase 1 trial in healthy volunteers is a randomized, double-blind, single- and multiple- ascending dose study evaluating the safety, tolerability, pharmacokinetic/pharmacodynamic and immunogenicity of ALTB-268.
The Phase 1 study will examine the safety and tolerability in healthy volunteers with anticipated interim data in 1H 2023, with plans to follow with initiation of a Phase 2 study in ulcerative colitis.
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