AltruBio Announces Poster Presentation on Immune Checkpoint Enhancer, ALTB-168 at Crohn's & Colitis Congress 2023
SAN FRANCISCO, Jan. 19, 2023 (GLOBE NEWSWIRE) -- AltruBio Inc. (“AltruBio” or “the Company”), a clinical stage biotech company dedicated to the development of novel therapeutics for the treatment of immunological diseases with high unmet medical needs, today announced that David T. Rubin, M.D., Professor of Medicine at the University of Chicago and AltruBio Scientific Advisory Board member, will share a poster presentation on first-generation immune checkpoint enhancer (ICE), ALTB-168 (neihulizumab), at the Crohn’s & Colitis Congress 2023, to be held in Denver, Colorado on January 19-21, 2023.
The poster being presented on-site by Dr. Rubin will provide data on the Phase 2 open label study of ALTB-168 (neihulizumab) in patients with moderately to severely active anti-TNFa and/or anti-integrin refractory ulcerative colitis (UC).
“With more than three million people in the U.S. suffering from inflammatory bowel disease, there remains a significant unmet need for novel therapies to achieve sustained remission,” said Dr. Rubin. “I am pleased to present results that demonstrate the safety and tolerability of neihulizumab as well as promising signals of response and remission in this particularly tough to treat group of patients.”
Jesse Hall, M.D., Chief Medical Officer of AltruBio, added, “We’re pleased to share data supporting favorable safety and clinical benefit as a result of downregulating activated T cells through the unique mechanism of action targeting PSGL-1. With the promising data of ALTB-168 in UC, our next generation ICE ALTB-268, a tetravalent version of ALTB-168, has been developed in a patient-friendly, subcutaneous dosage form and will expand the potential to treat patients suffering from a variety of autoimmune and immune-mediated inflammatory diseases, including UC. We look forward to sharing more clinical progress this year.”
The ALTB-168 (neihulizumab) Phase 2 trial is an open label, single arm, multiple dose proof of principle study to evaluate efficacy, safety, tolerability, and immunogenicity of ALTB-168 in patients with moderate to severe active UC who are refractory or intolerant to anti-TNFa and/or anti-integrin therapy. Two regimens were tested: 5 weekly IV doses plus 3 bi-weekly IV doses of 9 mg/kg ALTB-168 (5+3 regimen), and 8 weekly IV doses plus 2 bi-weekly IV doses of 9 mg/kg ALTB-168 (8+2 regimen). More information about the trial isavailable on clinicaltrials.gov (ClinicalTrials.gov Identifier: NCT03298022).
Data highlights include:
Details about the poster presentation are as follows:
Title: A Phase II Open Label Study of Neihulizumab, an anti-CD162 (PSGL-1 ) antibody, in patients with moderate to severe active, anti-TNFa and/or anti-integrin refractory ulcerative colitis
For more information and to register for the Crohn’s & Colitis Congress 2023, visit the conference website.
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