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Masonic Cancer Center, University of Minnesota to Present Data in Poster Presentation From the Phase 1 Clinical Trial to Evaluate HCW9218 in Solid Tumors At the SITC 37th Annual MeetingPresentation includes data on safety and dosage escalation No incidence of mucosal bleeding resulting from the HCW9218 TGF-ß trap HCW9218 is one of the lead product candidates of HCW Biologics Inc. MIRAMAR, Fla., Nov. 08, 2022 (GLOBE NEWSWIRE) -- HCW Biologics Inc. (the “Company” or “HCW Biologics”) (NASDAQ: HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation and age-related diseases, today announced that data will be presented at the 37th Annual Meeting of the Society for Immunotherapy of Cancer (“SITC”) from an ongoing Phase 1 clinical trial to evaluate HCW9218 in patients with chemo-refractory/chemo-resistant solid tumors, conducted by the Masonic Cancer Center, University of Minnesota. A poster will be presented by Melissa A. Geller, M.D., M.S., Professor and Division Director of Gynecologic Oncology in the Department of Obstetrics, Gynecology and Women’s Health at the University of Minnesota who serves as a Principal Investigator of this trial. HCW Biologics has also initiated a Company-sponsored Phase 1b/2 clinical trial in patients with chemo-refractory/chemo-resistant pancreatic cancer and dosed two patients in October 2022. The Company selected chemo-refractory/chemo-resistant solid tumors for its first clinical indications because solid tumor cancers are characterized by a dense fibrotic stroma or desmoplasia that allows a tumor to shield itself from standard-of-care treatment, such as chemotherapy and immune-checkpoint inhibitors. The immunosuppressive growth factor, TGF-ß, plays a major role in formation of desmoplasia and promoting tumor growth and metastasis. HCW9218 is an injectable, bifunctional fusion protein complex designed to simultaneously stimulate effector T cell and natural killer cell responses and inhibit the activity of TGF-ß and its immunosuppressive effect. The Company believes these combined capabilities may define a new category of cancer treatment accomplished by modifying factors related to drug resistance and disease recurrence, especially for the most difficult to treat cancers that are chemo-refractory/chemo-resistant. Details of the presentation are as follows: Title: A phase I study of HCW9218, a bifunctional TGF-ß antagonist/IL-15 protein complex, in advanced solid tumors Date/Time: November 10, 2022, 9 a.m. to 9 p.m., Eastern Time and November 11, 2022, 9 a.m. to 8:30 p.m., Eastern Time The presentation will be made available on the Company’s website in the Investors section under Events & Presentations, following the conference. For conference information, visit www.sitcancer.org/2022/program/annual-meeting. About the HCW9218 Phase 1 Clinical Trial Sponsored by Masonic Cancer Center About Masonic Cancer Center: About HCW Biologics: HCW Biologics is a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between chronic, low-grade inflammation, and age-related diseases, such as cancer, cardiovascular diseases, diabetes, neurodegenerative diseases, and autoimmune diseases. The Company has combined deep understanding of disease-related immunology with its expertise in advanced protein engineering to develop the TOBI™ (Tissue factOr-Based fusIon) discovery platform. The Company uses its TOBITM discovery platform to generate designer, novel multi-functional fusion molecules with immunotherapeutic properties. The invention of HCW Biologics’ two lead molecules, HCW9218 and HCW9302, was made via the TOBI™ discovery platform. The Masonic Cancer Center, University of Minnesota, has initiated a Phase 1 clinical trial to evaluate HCW9218 in chemo-refractory/chemo-resistant solid tumors that have progressed after prior chemotherapies. The Company has initiated a Company-sponsored Phase 1b/2 clinical trial to evaluate HCW9218 in chemo-refractory/chemo-resistant advanced pancreatic cancer. The Company’s lead molecule for its regulatory T cell expansion program, HCW9302, is currently undergoing IND-enabling studies for an autoimmune indication. Forward Looking Statements: Company Contact: |