Kronos Bio to Present Preclinical Data for KB-0742, an Oral CDK9 Inhibitor Targeting MYC-amplified Cancers, in Pediatric Cancer Models in Poster Presentation at EORTC-NCI-AACR 2022
SAN MATEO, Calif. and CAMBRIDGE, Mass., Oct. 12, 2022 (GLOBE NEWSWIRE) -- Kronos Bio, Inc. (Nasdaq: KRON), a company dedicated to transforming the lives of those affected by cancer, today announced that it will present preclinical data in a poster at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain. The meeting will be held from Oct. 26-28, 2022.
The poster will include preclinical data demonstrating that Kronos Bio’s internally discovered oral CDK9 inhibitor, KB-0742 induced regressions in a preclinical model of MYCN-amplified neuroblastoma tumors and inhibited growth in patient-derived xenograft (PDX) models of transcriptionally addicted Ewing sarcoma (EW) and alveolar rhabdomyosarcoma (ARMS).
This is the first preclinical analysis to support the investigational compound’s potential in pediatric tumors. KB-0742 is being developed for the treatment of MYC-amplified and transcriptionally addicted solid tumors and is currently being assessed as part of an ongoing Phase 1/2 study. Kronos Bio remains on track to provide an update on the study, including the Recommended Phase 2 Dose (RP2D) in the fourth quarter.
The abstract is now available on the conference website. Details of the poster presentation are as follows:
Poster Title: Regulation of oncogenic transcription and tumor growth in pediatric cancers by the CDK9 inhibitor KB-0742
About Kronos Bio, Inc.
Kronos Bio is based in San Mateo, Calif., and has a research facility in Cambridge, Mass. For more information, visit www.kronosbio.com or follow the company on LinkedIn.
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