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Global Amyloidosis Market Spotlight Report 2021: GlaxoSmithKline, Bristol Myers Squibb, and Pfizer have the Highest Number of Completed Clinical Trials with 5 Each
[January 28, 2022]

Global Amyloidosis Market Spotlight Report 2021: GlaxoSmithKline, Bristol Myers Squibb, and Pfizer have the Highest Number of Completed Clinical Trials with 5 Each


DUBLIN, Jan. 28, 2022 /PRNewswire/ -- The "Market Spotlight: Amyloidosis" report has been added to ResearchAndMarkets.com's offering.

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This Market Spotlight report covers the Amyloidosis market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, upcoming and regulatory events, probability of success, and a 10-year disease incidence forecast, as well as presenting drug-specific revenue forecasts.

Key Takeaways

  • The publisher estimates that in 2017, there were approximately 90,500 incident cases of amyloidosis worldwide, with the highest proportion being the primary (amyloid light-chain; AL) amyloidosis type.
  • Among multiple myeloma cases, the publisher estimates there were approximately 19,300 incident cases of AL amyloidosis worldwide in 2017.
  • Approved drugs in the amyloidosis space target cluster of differentiation 38 and transthyretin. These drugs are administered via intravenous, subcutaneous, and oral routes.
  • There are equal numbers of industry-sponsored drugs in active clinical development for amyloidosis in Phase I and Phase III. Therapies in development for amyloidosis focus on targets such as transthyretin, amyloid - light chain, cluster of differentiation 38, angiogenesis, DNA, alpha-synuclein, amyloid beta/amyloid plaques, tau proteins, and catechol-O-methyltransferase. These therapies are administered via the intravenous, oral, and subcutaneous routes.
  • High-impact upcoming events for drugs in the amyloidosis space comprise topline Phase III trial results for AG10, Onpattro, CAEL-101, and AKCEA-TTR-LRx, and an expected supplemental CHMP opinion for Darzalex Faspro.
  • The overall likelihood of approval of a Phase I metabolic-other asset is 7.9%, and the average probability a drug advances from Phase III is 70.6%. Drugs, on average, take 9.0 years from Phase I to approval, compared to 9.1 years in the overall metabolic space.
  • The distribution of clinical trials across Phase I-IV indicates that the majority of trials for amyloidosis have been in the early and mid-phases of development, with 75% of trials in Phase I-II, and 25% in Phase III-IV.
  • The US leads in terms of the number of amyloidosis clinical trials globally. The UK leads the major European markets, while Japan has the top spot in Asia.
  • GlaxoSmithKline, Bristol Myers Squibb, and Pfizer have the highest number of completed clinical trials for amyloidosis, with five trials each.
  • GlaxoSmithKline leads industry sponsors with the highest overall number of clinical trials for amyloidosis.



Key Topics Covered:

OVERVIEW


KEY TAKEAWAYS

DISEASE BACKGROUND

  • Subtypes

TREATMENT

  • Chemotherapy
  • Targeted therapy
  • Surgery
  • Bone marrow/stem cell transplantation
  • Palliative or supportive care

EPIDEMIOLOGY

  • Amyloidosis incidence methodology
  • Amyloidosis in multiple myeloma incidence methodology
  • TTR amyloidosis

MARKETED DRUGS

PIPELINE DRUGS

RECENT EVENTS AND ANALYST OPINION

  • Vutrisiran for hATTR Amyloidosis with Polyneuropathy (April 19, 2021)
  • Vutrisiran for hATTR Amyloidosis with Polyneuropathy (January 7, 2021)

KEY UPCOMING EVENTS

KEY REGULATORY EVENTS

  • Alnylam's Vutrisiran NDA Incorporates Earlier Onpattro Trial In hATTR Amyloidosis Patients
  • US FDA Oncology Applications: Real-Time Review And Breakthrough Pathway Show Durable Appeal

PROBABILITY OF SUCCESS

REVENUE OPPORTUNITY

CLINICAL TRIAL LANDSCAPE

  • Sponsors by status
  • Sponsors by phase
  • Recent events

BIBLIOGRAPHY

APPENDIX

For more information about this report visit https://www.researchandmarkets.com/r/d7ubbi

Media Contact:

Research and Markets
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Cision View original content:https://www.prnewswire.com/news-releases/global-amyloidosis-market-spotlight-report-2021-glaxosmithkline-bristol-myers-squibb-and-pfizer-have-the-highest-number-of-completed-clinical-trials-with-5-each-301470612.html

SOURCE Research and Markets


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