VectivBio Announces Third Quarter 2021 Business Update
-Pivotal STARS Program of Apraglutide in SBS-IF Progressing with Majority of Sites Activated and Screening; STARS Nutrition Interim Results Expected 1H 2022-
-Expanded Rare Disease Pipeline with the Acquisition of CoMET Small Molecule Platform for Inherited Metabolic Diseases (IMDs)-
-IND Application for Apraglutide for Acute Graft-Versus-Host Disease (aGVHD) Cleared by FDA; First Patient in Expected 1Q 2022, Interim Data Expected 2H 2022-
BASEL, Switzerland, Nov. 10, 2021 (GLOBE NEWSWIRE) -- VectivBio Holding AG (“VectivBio”) (Nasdaq: VECT), a clinical-stage biopharmaceutical company pioneering novel transformational treatments for severe rare conditions, today provided a business update for the third quarter ended September 30, 2021.
“VectivBio made tremendous progress this quarter, including the achievement of key milestones and strategic advancements that have expanded the breadth of our efforts to transform the treatment of rare conditions,” said Luca Santarelli, M.D., Ph.D., Founder and Chief Executive Officer of VectivBio. “In October, the FDA cleared our IND to initiate STARGAZE, a Phase 2 trial evaluating apraglutide for the treatment of aGVHD, the second indication for our lead candidate. We expect the first patient to enter this trial during the first quarter of next year and expect initial interim data in the second half of 2022. Notably, this follows successful initiations earlier this year of our pivotal program of apraglutide in patients with short bowel syndrome with intestinal failure (SBS-IF), encompassing the Phase 3 STARS study and the Colon-in-Continuity (CIC) focused STARS Nutrition study. We’re happy to report that the Phase 3 Trial is steadily progressing, with the majority of sites activated and screening. We also expect to announce interim results for the STARS Nutrition study in the first half of 2022. These results aim to provide clinically meaningful evidence that apraglutide can improve intestinal absorption and reduce parenteral support volume in CIC patients who represent the majority of SBS and respond poorly to current standard-of-care GLP-2 treatment.”
Dr. Santarelli continued, “Additionally, in September, we acquired CoMET, a modular platform to develop small molecules addressing the deficit of Coenzyme A-mediated energy metabolism that underlies often-fatal and currently intractable inherited metabolic diseases. With this transaction, we have immediately added four new programs to our R&D pipeline and laid a foundation supporting our vision to become a fully integrated rare disease company.”
Third Quarter 2021 and Recent Business Updates
Apraglutide: Next-generation, long-acting synthetic GLP-2 analog being developed for a range of rare gastrointestinal diseases where GLP-2 can play a central role in addressing disease pathophysiology, including short bowel syndrome with intestinal failure (SBS-IF) and Acute Graft-Versus-Host Disease (aGVHD).
Apraglutide for SBS-IF:
Apraglutide for aGVHD:
CoMET Platform: Modular, small molecule platform applying innovative chemistry to address severe Inherited Metabolic Diseases (IMDs) in pediatric populations with a deficit of energy metabolism caused by the depletion of functional Coenzyme A (“CoA”).
About VectivBio AG
With the CoMET platform, we also aim to address severe and often fatal Inherited Metabolic Diseases (IMDs) in pediatric populations. IMDs represent a group of genetic disorders in which dysregulated Co-enzyme A (CoA) metabolism is a key pathophysiological defect. Candidates from the CoMET platform are initially being evaluated in methylmalonic acidemia (MMA) and propionic acidemia (PA). Additional targets include urea cycle disorders, fatty acid oxidation disorders, and amino acidopathies.