PARIS® Test Identified Effective Therapy for Patient with Terminal Ovarian Cancer
SEATTLE, Sept. 13, 2021 (GLOBE NEWSWIRE) -- SEngine Precision Medicine announces dramatic results for a 52-year-old patient with terminal ovarian cancer who received the PARIS® Test in early summer 2020. An interim case summary was included in SEngine’s poster presentation at the AACR 2021 annual meeting.
The patient’s oncologist, Heidi Gray, MD, who specializes in ovarian cancer at the University of Washington, ordered the PARIS® Test. The Test pre-screens a broad panel of cancer drugs on live patient-derived tumor cells with a battery of oncology drugs selected from a menu of targeted and less-toxic medications. The results are analyzed using AI-driven computational tools culminating in a clinically actionable drug sensitivity report.
“This patient’s cancer was not responding to conventional chemotherapy treatments, and I was running out of options. Therefore, we were hopeful the test would have the potential to find an effective therapy,” said Dr. Gray.
The PARIS® Test performed 42 highly miniaturized robotics-executed drug assays in parallel on this patient’s live cancer cells and a report ranking drug sensitivities was delivered to Dr. Gray. The PARIS® report informed the oncologist as to which drugs demonstrated activity, as well as those that did not. The results indicated that a targeted drug, FDA approved for mantle cell lymphoma and chronic lymphocytic leukemia, was the most effective among all drugs tested to kill this patient’s cancer. Much like finding a match for an organ transplant, the PARIS® Test found a drug match for this patient.
Within a month of treatment wit the PARIS®-guided therapy, the cancer marker CA125 decreased by half, and after 6 months the patient was well and traveling for vacation. During a recent monthly tumor board, Dr. Gray commented, “It is a miracle of modern science. The patient has gone from being hospitalized on IVs last winter to now being able to eat and feeling well enough to travel to New Orleans. Her tumor marker CA125 has decreased to below 20 Units/mL, indicating cancer remission, and her scans show partial response.” The patient continues to be well to date.
“This case illustrates the power of pre-testing cancer drugs to help patients and oncologists identify a personalized therapeutic path,” commented Carla Grandori, MD, Ph.D., co-founder and Chief Executive Officer of SEngine Precision Medicine. “While this case stands out, SEngine has also presented a large cohort of patients with advanced cancers who received the PARIS® Test at the ASCO annual meeting this year. The results indicate the value of the PARIS® Test for physicians to advance personalized oncology in the clinic.”
About PARIS® Test
About SEngine Precision Medicine
Killer Video Surveillance Solutions Across the Entire Cannabis Supply Chain
Mistakes VARs Can't Afford to Make in the Cannabis Market
Setting the Stage for 6G