Editas Medicine and IDT Announce Publication in Nature Communications of Research Data Supporting the Use of Optimized AsCas12a Nuclease Variant, Alt-R A.s. Cas12a (Cpf1) Ultra, in Researching the Potential of Gene-Edited Cell Medicines
CAMBRIDGE, Mass. and CORALVILLE, Iowa, July 29, 2021 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, and Integrated DNA Technologies, Inc. (IDT), a leading comprehensive genomics research solutions provider, today announced the publication of research data demonstrating the advantages of Alt-R™ A.s. Cas12a (Cpf1) Ultra, an engineered AsCas12a nuclease variant, as a tool to eventually enable the development of gene-edited cell medicines. The findings were published in the journal Nature Communications.
“We are thrilled Nature Communications published this collaborative paper demonstrating the advantages of Alt-R A.s. Cas12a (Cpf1) Ultra using multiple pre-clinical models, which has enabled Editas to continue our research and development for gene edited cell medicines,” said, Chris Wilson, Ph.D., Vice President, Lead Discovery, Editas Medicine. “Alt-R A.s. Cas12a (Cpf1) Ultra has shown to substantially improve upon the restricted target space and limited specificity of SpCas9, the most widely used Cas nuclease, and the low editing efficiency of wild type AsCas12a, creating what we believe to be a best-in-class nuclease with editing efficiency near 100 percent across sites in multiple cell lines and high on-target specificity. We believe this proprietary nuclease could have important applications in the development of novel therapies for serious genetic diseases such as sickle cell disease. In addition, we see significant opportunities to create engineered cell therapies for cancer.”
“This exciting research demonstrates that Alt-R A.s. Cas12a (Cpf1) Ultra is a robust gene editing tool while maintaining our desired on-target specificity, making it ideal for complex genomic editing applications,” said Chris Vakulskas, Director of Enzyme Evolution, IDT. “The on-target editing efficiency of Alt-R A.s. Cas12a (Cpf1) Ultra has great potential to expand the genome editing space, alleviate off-targeting editing concerns often observed with SpCas9 enzymes, and reduce the complexity of guide RNA manufacturing.”
The published results detail a directed evolution in bacteria to identify a highly active AsCas12a mutant, Alt-R A.s. Cas12a (Cpf1) Ultra, and demonstrate the variant’s superior on-target editing efficacy compared to Cas9 and AsCas12a. The paper summarizes several experiments of Alt-R A.s. Cas12a (Cpf1) Ultra tha demonstrated dramatically elevated knock-out and knock-in efficiency in both cancer cell lines and in human primary cells such as hematopoietic stem and progenitor cells (HSPCs), induced pluripotent stem cells (iPSCs), T cells, and natural killer (NK) cells. Overall, the results support further research for the use of Alt-R A.s. Cas12a (Cpf1) Ultra as an advanced CRISPR nuclease with significant potential future applications.
About Editas Medicine
Editas Medicine Forward-Looking Statements
Editas Medicine Contacts: Media Cristi Barnett (617) 401-0113 firstname.lastname@example.org Investors Ron Moldaver (617) 401-9052 email@example.com IDT Contacts: Media IDT Public Relations 800-328-2661 (USA & Canada) +1 319-626-8400 (outside USA) firstname.lastname@example.org www.idtdna.com
Ease Interoperability in Smart Cities - How Standards Can Prevent Vendor-lock-in
Driving Production Lessons from the Automotive Industry
Moving Things and 5G Low Latency