Allogene Therapeutics to Present Data from its Anti-CD19 AlloCAR T™ Therapy Program in Relapsed/Refractory Non-Hodgkin Lymphoma at the American Society of Clinical Oncology
SOUTH SAN FRANCISCO, Calif. and PARIS, April 28, 2021 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T™) therapies for cancer, in collaboration with its development partner Servier, an independent international pharmaceutical company, today announced that longer-term follow-up data from Allogene’s dose escalation Phase 1 ALPHA study of ALLO-501 in relapsed/refractory non-Hodgkin lymphoma (NHL) will be jointly presented with initial data from the ALPHA2 trial of ALLO-501A at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting being held virtually June 4 - 9, 2021. A separate poster presentation will detail safety and biomarker findings from ALLO-647, Allogene’s wholly owned antibody used for lymphodepletion with fludarabine (Flu)/cyclophosphamide (Cy) in patients with relapsed/refractory non-Hodgkin lymphoma and multiple myeloma.
These Phase 1 trials are designed to assess the safety and tolerability at increasing dose levels of ALLO-501, ALLO-501A and ALLO-647 in the most common NHL subtypes of relapsed/refractory diffuse large B-cell lymphoma or follicular lymphoma. ALLO-501A, a next-generation anti-CD19 AlloCAR T™ intended for Phase 2 development in diffuse large B cell lymphoma (DLBCL), eliminates the rituximab recognition domains in ALLO-501, which could allow for use in a broader patient population, including NHL patients with recent rituximab exposure.
“We are excited to present the first clinical data on ALLO-501A, our anti-CD19 AlloCAR T candidate intended for registrational trials in DLBCL, along with longer-term follow up from ALPHA, our first Phase 1 study of ALLO-501,” said Rafael Amado, MD, Executive Vice President of Research & Development and Chief Medical Officer of Allogene. “Over the past year, we have moved quickly and diligently to advance multiple AlloCAR T programs into the clinic using innovative technologies and across a variety of malignancies. We’re looking forward to discussing our progress in these two foundational studies during our virtual CD19 Forum.”
Allogene will host a virtual CD19 Forum for investors and other interested parties on May 19, 2021 at 2:30 p.m. Pacific Time/5:30 p.m. Eastern Time. The Forum will include data being presented at the virtual 2021 ASCO Annual Meeting along with discussion from clinical investigators and Allogene’s vision for the future of its AlloCAR T platform.
Allogene presentations at the virtual 2021 ASCO Annual Meeting:
First-in-human data of ALLO-501A, an allogeneic chimeric antigen receptor (CAR) T-cell therapy and ALLO-647 in relapsed/refractory large B-cell lymphoma (R/R LBCL): ALPHA2 study.
Safety and PK/PD of ALLO-647, an anti-CD52 antibody, with fludarabine (Flu)/cyclophosphamide (Cy) for lymphodepletion in the settig of allogeneic CAR-T cell therapy.
Poster Session Title: Developmental Therapeutics—Immunotherapy
Abstract # 2527
Session Release Date: June 4, 2021
Virtual CD19 Forum
About ALLO-501 (Allogene Sponsored)
About ALLO-501A (Allogene Sponsored)
About Allogene Therapeutics
A leader in cardiology, the ambition of the Servier Group is to become a recognized and innovative player in oncology. Its growth is based on a sustained commitment to cardiovascular and metabolic diseases, oncology, and immuno-inflammatory and neurodegenerative diseases. To promote access to healthcare for all, the Servier Group also offers a range of quality generic drugs covering most pathologies. More information: www.servier.com
Servier Group press contacts:
Cautionary Note on Forward-Looking Statements for Allogene
AlloCAR T™ is a trademark of Allogene Therapeutics, Inc.
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