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Finnish researchers introduce a nasal COVID vaccineJOENSUU, Finland, March 8, 2021 /PRNewswire/ -- Rokote Laboratories Finland Ltd., a newly-founded academic spin-out based in Finland is working to develop and introduce to the markets a nasal spray vaccine against COVID. The vaccine is based on research carried out at the University of Helsinki and the University of Eastern Finland. The vaccine uses gene transfer technology developed at the University of Eastern Finland by Academy Professor Seppo Ylä-Herttuala's research group, and the technology has already been successfully used in several clinical trials using gene therapy to treat cardiovascular diseases and cancer. The vaccine uses a safe adenovirus carrier that contains a cloned DNA strand, which causes nasopharyngeal cells to produce the virus protein which, in turn, produces a response to the vaccine. There is no actual SARS-CoV-2 virus in the vaccine. Preliminary results show that the vaccine has performed well in animal studies, and clinical testing in humans will start within a few months. Nasal delivery was chosen as the new vaccine's method of administration because the virus is also naturally transmitted through the airways. Indeed, nasal administration seems to induce a wider immune response than intramuscular administration. "Vaccines injected intramuscularly produce IgG antibodies in the bloodstream, but nasal vaccines also produce an IgA response that protects mucous membranes. We assume that this can also prevent those who have received the vaccine from transmitting the virus," Academy Professor Seppo Ylä-Herttuala from the University of Eastern Finland says. According to him, the currently ongoing vaccination programmes do not eliminate the need for new vaccines, as new variants are expected to cause new waves of infection. The company will carry out the first clinical vaccine trials in Finland. In Kuopio, there is already the commercial technology needed to produce the vaccine. The founders and board members of Rokote Laboratories Finland Ltd. are the vaccine developers Academy Professor Seppo Ylä-Herttuala from the University of Eastern Finland, Professor Kalle Saksela and Professor Kari Alitalo from the University of Helsinki, and Mr Pasi Kemppainen, MSc (Techn.). The University of Helsinki and the University of Eastern Finland are also co-founders of, and shareholders in, the company. According to Mr Kemppainen, the company is now negotiating on funding to ensure further development of the vaccine and its moving towards clinical trials. After being granted a marketing authorisation, the vaccine could ensure Finnish and European security of supply, and vaccine self-sufficiency. "The vaccine can be manufactured in considerable quantities here in Kuopio and, in the long term, it can also be licensed outside Europe. The current focus is, of course, on the COVID vaccine, but the same method can also be used to develop vaccines against other viruses," Mr Kemppainen says. For further information, please contact: Academy Professor Seppo Ylä-Herttuala Professor Kalle Saksela Pasi Kemppainen This information was brought to you by Cision http://news.cision.com The following files are available for download:
View original content:http://www.prnewswire.com/news-releases/finnish-researchers-introduce-a-nasal-covid-vaccine-301242174.html SOURCE University of Eastern Finland |