Gain Therapeutics Announces Research Collaboration with Sumitomo Dainippon Pharma Co., Ltd to Advance Gain's Lysosomal Enzyme Allosteric Regulator Program
BETHESDA, Md., Sept. 10, 2020 (GLOBE NEWSWIRE) -- Gain Therapeutics, Inc., (“Gain”) a biotechnology company focused on redefining drug discovery by identifying and optimizing allosteric binding sites that have never before been targeted, today announced that it has entered into a strategic research collaboration agreement with Sumitomo Dainippon Pharma Co., Ltd. for the research and development of structurally targeted allosteric regulators to restore functional activity of defective lysosomal emzymes in rare genetic and demyelinating diseases.
“We are pleased that a company as renowned as Sumitomo Dainippon Pharma has seen the value in our program to develop oral treatments for rare genetic and demyelinating diseases, such as lysosomal storage diseases,” said Dr. Manolo Bellotto, President and General Manager at Gain. “Sumitomo Dainippon Pharma’s large-scale R&D capabilities and dedication to rare disease will enormously support acceleration of our research program as we apply Gain’s Site-Directed Enzyme Enhancement Therapy (SEE-Tx™) platform to discover ‘first-in-class’ regulator molecules that can potentially prevent demyelination by improving lysosomal enzyme function, both by restoring mutant enzyme activity and protecting and enhancing wildtype enzyme activity. We are looking forward to advancing this research and getting another step closer to finding new options for children affected by these lethal disorders.”
Under the terms of the agreement, Gain and Sumitomo Dainippon Pharma will collaborate to identify and develop small molecules targeting allosteric sites in lysosomal enzymes for the treatment of rare genetic and demyelinating diseases.
Eric Richman, Chief Executive Officer of Gain, added, “Our technology enables a new frontier of medicines that target previously ‘undruggable targets’ which has the potential to address unmet medical needs of patients suffering fro debilitating central nervous system and metabolic disorders. Given the work that Gain Therapeutics has completed to date demonstrating its ability to identify key allosteric drug targets for the enhancement of mutated disease-causing enzymes, we believe there is strong potential for us to collaboratively develop leading drug candidates for the treatment of demyelinating lysosomal storage diseases, with the prospect of extending to other demyelinating diseases, as well. We look forward to a productive collaboration.”
About Gain Therapeutics, Inc.
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