Rubius Therapeutics Highlights Preclinical Data for RTX-321, a Red Cell Therapeutic™ Oncology Product Candidate for HPV-Positive Cancers, at the American Association of Cancer Research Virtual Annual Meeting II
CAMBRIDGE, Mass., June 22, 2020 (GLOBE NEWSWIRE) -- Rubius Therapeutics, Inc. (Nasdaq: RUBY), a clinical-stage biopharmaceutical company that is genetically engineering red blood cells to create an entirely new class of cellular medicines, today announced the presentation of preclinical data supporting its lead artificial antigen-presenting cell (aAPC) program, RTX-321, for the potential treatment of human papillomavirus (HPV) 16-positive cancers during the American Association for Cancer Research (AACR) Virtual Annual Meeting II.
“These preclinical data presented at AACR suggest that RTX-321 may promote epitope spreading, meaning that RTX-321 may induce the expansion of an immune response to secondary epitopes, or antigens, that are not expressed on RTX-321. This finding is important because it suggests that RTX-321 may create a broad and effective immune response against multiple tumor antigens,” said Laurence Turka, M.D., chief scientific officer of Rubius Therapeutics. “Additionally, the preclinical surrogate of RTX-321 induces tumor-specific memory, potentially enabling the body to remember a cancer’s identity, which is critical to providing long-term protection from recurrence of the tumor. Taken together, these findings support the potential of RTX-321 as an effective antigen-specific therapy for HPV 16-positive cancers. We plan to file the Investigational New Drug application for this program by the end of 2020.”
RTX-321 is an investigational allogeneic aAPC therapy tht is engineered to induce a tumor-specific immune response by expanding antigen-specific T cells. RTX-321 expresses an HPV peptide antigen bound to major histocompatibility complex (MHC) class I proteins, 4-1BBL – a co-stimulatory signal – and IL-12 – a cytokine – on the cell surface to mimic human T cell-APC interactions.
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