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ExCellThera announces results of clinical trial using ECT-001 for blood cancersMONTREAL, Dec. 04, 2018 (GLOBE NEWSWIRE) -- ExCellThera Inc., a biotechnology company delivering molecules and bioengineering solutions to expand stem and immune cells for therapeutic use, today announced results from the Phase I/II clinical trial using its lead technology, ECT-001, for allogeneic stem cell transplant. The results of the study were presented at the 2018 American Society of Hematology (ASH) Annual Meeting in San Diego and demonstrated conclusively that blood cells expanded for seven days with ECT-001 are effective at providing substantial clinical benefits when compared to standard of care for bone marrow transplants. “These results further validate our lead technology, ECT-001, which is also being used in an ongoing clinical trial for multiple myeloma and will be used in two new phase II studies scheduled to begin in Q1 2019,” said Dr. Guy Sauvageau, CEO and founder of ExCellThera. “The data presented at ASH shows that rapid engraftment of stem and immune cells expanded with ECT-001 can favorably compete – and improve upon – the current standard of care.” The presentation detailed results from 21 patients with high-risk hematologic malignancies and multiple comorbidities engrafted with blood cells expanded with ECT-001 as part of a Phase I/II multicentre trial. The study showed that a 7-day ECT-001 expanded single cord blood unit provided substantial clinical benefits, including faster engraftment, fewer infectious complications, beter HLA matching and very low treatment-related mortality, all the while saving production and hospitalization time and costs. Furthermore, a very low rate of significant chronic graft-versus-host disease (GvHD) was observed and patients’ overall quality of life, as measured by GvHD and relapse free survival (GRFS), is excellent. With a median follow up of 14 months, there has been no moderate-severe chronic GvHD, and despite a median comorbidity index of 2 and some very high-risk patients, there has been only one (1) treatment-related mortality and only three (3) cases of relapse. At 12 months, overall survival, progression-free survival and GRFS were excellent at 95%, 77% and 67%, respectively. Immunosuppressive therapy was discontinued at 12 months in 76% of patients. Dr. Sauvageau also commented that “These results indicate that ECT-001 expanded single cord transplants combine the advantages of conventional grafts using bone marrow (low treatment-related mortality), peripheral blood (low relapse) and cord blood (accessibility, low relapse and chronic GvHD) in a single, low cost, easy to produce 7-day culture product, which could lead to a paradigm shift in bone marrow transplantation.” About ECT-001 About ExCellThera Inc. Contacts: Investor Inquiries David Millette Chief Financial and Legal Officer [email protected] Media Inquiries Lisa Willemse Chief Marketing Officer [email protected] |