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OSE Immunotherapeutics Announces Publication in Nature Communications on Anti-IL-7 Receptor Antagonist (OSE-127)
NANTES, France, Oct. 29, 2018 (GLOBE NEWSWIRE) -- OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnémo: OSE) today announced publication in Nature Communications of its monoclonal antibody (OSE-127) targeting IL-7 Receptor (IL-7R) with full antagonist properties. This compound controls antigen-specific memory T cells mimicking pathogenic situations and chronic inflammation. As IL-7 is the fuel driving chronic autoimmune and inflammatory diseases, this interleukin regulates mainly T cell proliferation and survival. Mature T cells express high levels of the IL-7 Receptor (IL-7R) except regulatory T cells expressing low level of IL-7 receptor. In the article, the authors develop an original mechanism of action as in vivo the anti-IL-7 receptor mAb (monoclonal antibody OSE-127) targeting IL-7R demonstrates full antagonist properties related to its particular structure blocking 2 sites of IL-7R (“Sites 1 and 2b”). Two other mAbs, also against IL-7R but targeting only Site 1 of IL-7R, were tested in parallel and presented paradoxical agonist and antagonist properties limiting their efficacy. In addition, the transcriptome (gene expression measured by RNA-SEQ) of human peripheral blood mononuclear cells (PBMCs representing lymphocyte types and monocytes) was analyzed after incubation with the two types of IL-7R antagonists (Site 1 restricted mAbs or “Sites 1 and 2b” mAb/OSE-127). The results on human blood cells showed significant differences, as Site 1 restricted antibodies induced significant translational modifications of human PBMCs compatible with T cell activation and inflammatory responses, while” Sites 1 and 2b” mAb/OSE-127 did not induce such activation. OSE-127 is targeting selectively pathogenic effector cells while preserving quiescent T cells and natural T cell regulators. These significant features are very important for clinical applications in autoimmune diseases and chronic inflammation. Alexis Peyroles, CEO of OSE Immunotherapeutics, said, “We warmly congratulate all the first-class OSE team and the network of experts involved for this major achievement. OSE-127, being developed in partnership with Servier (1), is expected to enter phase 1 clinical phase and we are focused on this next coming step.” *“IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation” 1 Centre de Recherche en Transplantation et Immunologie (CRTI) UMR1064, INSERM, Université de Nantes, Nantes, France. 2 OSE Immunotherapeutics, Nantes, France.3 Quality Assistance, Thuin, Belgium. 4 ARNA laboratory, Université de Bordeaux, INSERM U1212, CNRS UMR5320, IECB, Bordeaux, France. 5 Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France. ([1]) Servier is an independent international pharmaceutical company governed by a foundation with Headquarters based in France. ABOUT OSE Immunotherapeutics Click and follow us on Twitter and Linkedln Contacts
Forward-looking statements These forward-looking statements include statements typically using conditional and containing verbs such as “expect”, “anticipate”, “believe”, “target”, “plan”, or “estimate”, their declensions and conjugations and words of similar import. Although the OSE Immunotherapeutics management believes that the forward-looking statements and information are reasonable, the OSE Immunotherapeutics’ shareholders and other investors are cautioned that the completion of such expectations is by nature subject to various risks, known or not, and uncertainties which are difficult to predict and generally beyond the control of OSE Immunotherapeutics. These risks could cause actual results and developments to differ materially from those expressed in or implied or projected by the forward-looking statements. These risks include those discussed or identified in the public filings made by OSE Immunotherapeutics with the AMF. Such forward-looking statements are not guarantees of future performance. This press release includes only summary information and should be read with the OSE Immunotherapeutics Reference Document filed with the AMF on 26 April 2018, including the annual financial report for the fiscal year 2017, available on the OSE Immunotherapeutics’ website. Other than as required by applicable law, OSE Immunotherapeutics issues this press release at the date hereof and does not undertake any obligation to update or revise the forward-looking information or statements. |