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Global Label Free Detection (LFD) Market 2018-2023 - Surface Plasmon Resonance (SPR) Leads the Market in Technology Segment
DUBLIN, Oct. 1, 2018 /PRNewswire/ --
The "Global Label Free Detection (LFD) Market - Segmented by Product, Technology, Application, End-User, and Geography - Growth, Trends and Forecast (2018 - 2023)" report has been added to ResearchAndMarkets.com's offering.
 The global label free detection market is projected to grow at a CAGR of approximately 8% during the forecast period 2018-2023
The label free detection is a method for detecting biomolecules and their interactions. The LFD method has made tremendous advancements due to combination of knowledge in material sciences, computational design and nanofabrication. Partnerships between pharmaceutical companies and academic institutes and the rising number of drug discovery programs will boost market growth.
Innovations in Label-Free Detection Technologies
A label is any foreign molecule that is temporarily attached to the molecule of interest to detect molecular activity and presence. On the other hand, label free detection methods utilize the biophysical properties of the molecule such as molecular weight and refractive index to monitor molecular presence and activity. The main advantage in LFD techniques is that more direct information can be acquired as the method uses only native proteins and ligands.
Innovations in LFD techniques include modification of mass spectrometry to develop surface-enhanced laser desorption/ionization (SELDI) time of flight (TOF)- mass spectrometry (MS) which is an innovative approach that offers on-chip purification of the proteins of interest and subsequent ionization of the retained molecules to be detected. Other innovations in LFD techniques include the modification of surface plasmon resonance (SPR) to develop Localized Surface Plasmon Resonance (LSPR) which provides advantages like lower fabrication costs and higher sensitivity.
High Cost of Instruments
The use of protein labels imposes extra time and cost demands, and in certain cases interfere with molecular interaction by blocking binding sites, which ultimately leads to false negatives. On the contrary label free detection systems in assay technologies, provide rapid, often real-time approach to both biochemical and cell-based assay. Therefore in theory, label free detection techniques are cheaper than label based detection techniques, but in practice label free detection is used in tandem with label based detection techniques and not used exclusively. Moreover, label free detection is based on analysis of molecular properties which makes use of sophisticated devices imperative in label free detection.
Techniques involving micro-plates are preferred for label free detection systems but these systems are high cost equipment ranging in the price of 100,000 USD to 500,000 US, often equipped with gold sensors which puts additional replacement cost in scenarios where sensors need to replacement due to wear and tear issues. Consequently, the high cost of instruments in label free detection, is a limiting factor for the growth of the global LFD market. Other factor that is hindering market growth includes issues in sensitivity and throughput of label free detection techniques.
Surface Plasmon Resonance (SPR) Leads the Market in Technology Segment
On the basis of technology used, surface plasmon resonance (SPR) technology segment has the largest share in the global label free detection market. This is primarily due to its wide application range and compatibility with wide range of biomolecules. However, bio-layer interferometry segment is expected to grow at the fastest rate over the forecast period. Interferometry provides advantages like less fluctuation in the refractive index of the samples being tested and microfluidic-free nature of bio-layer interferometry label-free detection systems.
North America Dominates the Market
North America dominates the global label free detection market due to technological advancement and high government funding in the region. Asia-pacific region is expected to experience highest growth rate in global label free detection market, over the forecast period.
Key Developments in Label Free Detection Market
- Malvern Panalytical, a global leader in analytical characterization technology development, announced a collaboration with specialist Internet of Things (IoT) company, TetraScience, to deploy IoT-enabled capabilities and connectivity for its instruments. The objective of the collaboration will be to provide access to customized dashboards, data collection and analytics, and system scheduling and monitoring.
Key Topics Covered:
1. Introduction
1.1 Market Definition
2. Research Methodology
3. Executive Summary
4. Key Inferences
5. Market Overview
5.1 Current Market Scenario
5.2 Porter's Five Forces Analysis
6. Drivers, Restraints, Opportunities and Challenges Analysis (DROC)
6.1 Drivers
6.1.1 Innovations in Label-Free Detection Technologies
6.1.2 Increasing R&D Activities Through Research Partnerships Between Pharmaceutical Companies and Academic Institutes
6.1.3 Increasing Pharmaceutical Outsourcing
6.2 Restraints
6.2.1 High Cost of Instruments
6.2.2 Issues in Sensitivity and Throughput
6.3 Opportunities
6.3.1 Development of More Sensitive Label-Free Technologies
6.3.2 Rising Life Science Research Activities in Emerging Markets
6.4 Challenges
6.4.1 Unclear FDA Guidelines
7. Market Segmentation
7.1 By Product
7.1.1 Consumables
7.1.1.1 Biosensor Chips
7.1.1.2 Microplates
7.1.2 Instruments
7.2 By Technology
7.2.1 Mass Spectrometry
7.2.2 Surface Plasmon Resonance (SPR)
7.2.3 Bio-Layer Interferometry
7.2.4 Isothermal Titration Calorimetry
7.2.5 Differential Scanning Calorimetry
7.2.6 Quartz-Crystal Microbalance (QCM)
7.2.7 Other Lfd Technologies
7.3 By Application
7.3.1 Binding Kinetics
7.3.2 Binding Thermodynamics
7.3.3 Endogenous Receptor Detection
7.3.4 Hit Confirmation
7.3.5 Lead Generation
7.3.6 Other Applications
7.4 By End-User
7.4.1 Pharmaceutical & Biotechnology Companies
7.4.2 Academic & Research Institutes
7.4.3 Contract Research Organizations
7.5 By Geography
7.5.1 North America
7.5.1.1 US
7.5.1.2 Canada
7.5.1.3 Mexico
7.5.2 Europe
7.5.2.1 UK
7.5.2.2 Germany
7.5.2.3 France
7.5.2.4 Italy
7.5.2.5 Spain
7.5.2.6 Rest of Europe
7.5.3 Asia-Pacific
7.5.3.1 China
7.5.3.2 India
7.5.3.3 Japan
7.5.3.4 Australia
7.5.3.5 South Korea
7.5.3.6 Rest of Asia-Pacific
7.5.4 Middle East & Africa
7.5.4.1 GCC
7.5.4.2 South Africa
7.5.4.3 Rest of Middle East & Africa
7.5.5 South America
7.5.5.1 Brazil
7.5.5.2 Argentina
7.5.5.3 Rest of South America
8. Company Profiles & Competitive Landscape
8.1 Ametek Inc.
8.2 Corning Incorporated
8.3 Danaher Corporation
8.4 F. Hoffman-La Roche AG
8.5 General Electric Company
8.6 Hitachi High-Technologies Corporation
8.7 Horiba Ltd.
8.8 Malvern Panalytical
8.9 PerkinElmer Inc.
8.10 Shimadzu Corporation
8.11 TA Instruments
For more information about this report visit https://www.researchandmarkets.com/research/g3rt9l/global_label_free?w=5
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