[January 22, 2014]

Acceleron Announces Pricing of Public Offering of Common Stock

Acceleron Pharma Inc. (NASDAQ:XLRN), a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel protein therapeutics for cancer and rare diseases, today announced the pricing of a public offering of 2,400,000 shares of common stock at a public offering price of $50.00 per share, before underwriting discounts. In addition, Acceleron has granted the underwriters a 30-day option to purchase up to an additional 360,000 shares of common stock at the public offering price, less underwriting discounts. The offering is expected to close on or about January 28, 2014, subject to satisfaction of customary closing conditions.

Citigroup and Leerink Partners LLC are acting as joint book-running managers for the offering. Piper Jaffray & Co. is acting as lead manager and JMP Securities (News - Alert) is acting as co-manager for the offering.

A registration statement on form S-1 relating to these securities was declared effective on January 22, 2014. The offering will be made only by means of a prospectus, copies of which may be obtained from Citigroup, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY, 11717, or by email at [email protected], or by phone at 800-831-9146; or Leerink Partners LLC, Attention: Syndicate Department, One Federal Street, 37^th Floor, Boston, MA, 02110, or by email at [email protected], or by phone at 800-808-7525.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state or jurisdiction.

About Acceleron

Acceleron is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of novel protein therapeutics for cancer and rare diseases. The company is a leader in understanding the biology of the TGF-ß protein superfamily, a large and diverse group of molecules that are key regulators in the growth and repair of tissues throughout the human body, and in targeting these pathways to develop important new medicines. Acceleron has built a highly productive R&D platform that has generated innovative clinical and preclinical protein therapeutic candidates with novel mechanisms of action. These protein therapeutic candidates have the potential to significantly improve clinical outcomes for patients with cancer and rare diseases.

Cautionary Note on Forward-Looking Statements

This press release includes forward-looking statements, including statements relating to the anticipated closing of the underwritten public offering. Such forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements. Applicable risks and uncertainties include those identified under the heading "Risk Factors" included in the prospectus related to the offering, and in other filings that the Company may make with the SEC (News - Alert) in the future. The forward-looking statements contained in this press release reflect the Company's current views with respect to future events, and the Company does not undertake and specifically disclaims any obligation to update any forward-looking statements.

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