TMCnet Feature
June 27, 2022

Top Trends in Tablet Manufacturing 2022



The most common dosage form in pharmaceuticals is tablets, followed by capsules. Tablets are convenient dosage forms with cost effectiveness. The compression makes high-speed production and a high level of quality control possible. Since the onset of the compression process, tablet manufacturing is the favorite pharmaceutical process of big and small pharmaceutical industries, and biologics CDMOs and CROs. Constant upgrades in the tablet dosage form are ensured by the industry to advance patient healthcare. The equipment and techniques used in manufacturing are also upgraded.



1. Multilayer Tablets:

Dividing a tablet into layers provides separation of incompatible substances from each other by an intervening insulation layer. Another important advantage of layering is using different APIs in each layer required in the treatment and management of the same disease. It helps in patient compliance and lowers the burden of medicine intake. Same APIs with different drug release timings in different layers can ensure instant and sustained drug release in the body. The challenges like layer adhesion, dosage height, and weight regulations are faced in multilayer tablet manufacturing; but, flexible and compatible equipment can help in navigating through these challenges.

2. Micro Tablets:

To cater to the dosage needs of pediatric and geriatrics patients, pharmaceutical industries have introduced effervescent capsules and micro tablets. Micro tablets are preferred by most physicians because they are 2-3mm wide, which makes them very easy to swallow. Although the multi-top tools used for manufacturing micro tablets are very expensive and delicate with a more pressing need for parameter control, the results are worth it.

3. Built-In Chips:

The new technology of tablet manufacturing is being centered around the “chip in a tablet” innovation. It means the new tablets will be manufactured with built-in chips which can sense whether the tablet was taken by the patient and a signal will be sent to the relevant smartphone. It is suitable for patients having dementia-related pathologies because they mostly forget to take medicines. A chip inside the tablet will automatically send a notification to the healthcare provider if the tablet is taken. Otherwise, they can remind the patient to take their medications. The innovation is yet marginalized and centered around people most likely to forget to take their tablets but it has massive growth potential.

4. Digital Transformation:

Data collection is not a new terminology for pharmaceutical industries since they are centered around the collection and integration of data. But increased digital transformation of the pharmaceutical industry has made it possible to use the data in an innovative way to drive efficiency. The idea is based on a collection of massive data and inculcating it in such a way to predict the outcomes in various situations if they arise. Data is not just collected now, it is integrated into equipment to enrich the analytical outcomes. The model is trending but it requires experimental validation which is provided by certain tools as well.

5. Flexible R&D:

The new era of pharmaceutical development requires versatile R&D equipment. The idea is to create equipment that can create diverse prototypes with a simple change in software or accessory module. By adding containment and automation features, the investment is worth the costs.



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