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2018 Synribo (omacetaxine mepesuccinate; Teva/Hospira) Drugs Analysis - ResearchAndMarkets.comThe "Drugs Analysis: Synribo" report has been added to ResearchAndMarkets.com's offering. Synribo (omacetaxine mepesuccinate; Teva/Hospira) is a subcutaneously formulated, semisynthetic form of homoharringtonine, a naturally occurring alkaloid. In vitro studies show that Synribo binds to the ribosomal A-site cleft, inhibiting synthesis of a number of key oncoproteins. These oncoproteins include mcl-1 (an apoptosis inhibitor), cyclin-D1 (a promoter of cell proliferation), and c-Myc (a cell differentiation inhibitor). Synribo has suffered due to its late entrance into the chronc myeloid leukemia (CML) market and an unfavorable subcutaneous administration route compared to other marketed drugs. The drug has displayed activity against T315I mutation-positive disease, but Iclusig (ponatinib; Takeda/Incyte/Otsuka) displays similar activity and is available in an orally administered formulation. Therefore, Synribo will continue to see only minimal uptake in CML. Key Topics Covered: List of Figures Figure 1: Synribo for CML - SWOT analysis Figure 2: Drug assessment summary of Synribo for CML Figure 3: Drug assessment summary of Synribo for CML List of Tables Table 1: Synribo drug profile Table 2: Synribo pivotal trial data in CML For more information about this report visit https://www.researchandmarkets.com/research/vndn3j/2018_synribo?w=4 View source version on businesswire.com: http://www.businesswire.com/news/home/20180219005476/en/ |