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Mateon Therapeutics Announces Initial Pre-clinical Data on Combination of CA4P with Checkpoint Inhibitors
SOUTH SAN FRANCISCO, Calif., Feb. 13, 2017 (GLOBE NEWSWIRE) -- Mateon Therapeutics, Inc. (OTCQX:MATN), a biopharmaceutical company developing vascular disrupting agents (VDAs) for the treatment of orphan oncology indications, today announced encouraging preliminary data from four different syngeneic mouse models evaluating Mateon’s lead investigational drug CA4P in combination with checkpoint inhibitors. The most compelling results were found combining Mateon’s CA4P with an anti-CTLA4 antibody in an EMT-6 mammary model. In this study, 7 of 8 mice receiving the combination were tumor free at the study’s completion, compared to 1 of 8 in the CA4P monotherapy arm and 2 of 8 in the anti-CTLA4 antibody monotherapy arm. Three of four follow-up studies also demonstrated that CA4P combined with immune oncology agents delayed tumor growth. These studies were conducted in a larger tumor EMT-6 mammary model, a C3H mammary model and a CT26 colon model. The results provide additional supportive evidence that CA4P enhances anti-CTLA4 antibody activity, as well as initial evidence that CA4P enhances anti-PD-1 and PD-L1 activity. “We have seen in numerous earlier studies that CA4P, via vascular disruption, induces rapid and extensive necrotic tumor cell death,” stated William D. Schwieterman, M.D., President and Chief Executive Officer. “By causing this tumor cell necrosis, we believe that CA4P may enhance antigen presentation and T-cell activity within the tumors, increasing the effect of checkpoint inhibitors in tumors which do not respond to the immune oncology agents alone. Based upo the results of our initial pre-clinical studies, we are continuing with additional pre-clinical work in this field. Concurrently, our phase 2/3 FOCUS Study, evaluating CA4P in platinum-resistant ovarian cancer, continues to enroll patients and data from the first interim analysis is expected in April. We are also nearing completion of the 3rd dose cohort in our study of OXi4503 in acute myeloid leukemia.” Mateon reminds investors that a webcast of today’s presentation at the 19th Annual BIO CEO & Investor Conference at 5:30 pm eastern time will be available on the company’s website at www.mateon.com in “Events & Presentations” under the “Investors & News” tab. A replay of the webcast will also be available following the completion of the live event. About Mateon At Mateon, we believe that we can significantly improve cancer therapy by employing these two complementary approaches simultaneously. When utilized this way, VDAs obstruct existing blood vessels in the tumor leading to significant central tumor cell death while AAs prevent the formation of new tumor blood vessels. Mateon is committed to leveraging our intellectual property and the product development expertise of our highly skilled management team to enable VTT to realize its true potential and to bring much-needed new therapies to cancer patients worldwide. Safe Harbor Statement CONTACTS Investors: [email protected] 650-635-7000 Media: JPA Health Communications Nic DiBella [email protected] 617-945-5183 |