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Administration of Gelesis200 Increases Fullness and Satiety in People who are Overweight or Have ObesityGelesis, focused on developing first-in-class products to safely induce weight loss and improve glycemic control, today presented new data for its second product candidate, Gelesis200, at ObesityWeek 2016, the annual combined congress of the American Society for Metabolic and Bariatric Surgery and The Obesity Society. Data from this first-in-human study demonstrated that administration 10 minutes prior to a meal increased fullness throughout the entire day (P = 0.012). The purpose of the analysis was to determine the effect of Gelesis200 on subject-reported appetite scores following two or three administrations in a single day. In addition to increasing feelings of fullness, administration of Gelesis200 10 minutes prior to breakfast, lunch, and dinner resulted in greater satiety immediately preceding dinner (P = 0.017) and at 150 minutes and 180 minutes after dinner (P = 0.032 and P = 0.031, respectively). Gelesis200 was well-tolerated and its safety profile was similar to placebo in this study. "Gelesis200 is the second product comprised from our proprietary hydrogel platform, and it has been designed specifically for weight management as well as glycaemic control," said Hassan Heshmati MD, Gelesis Chief Medical Officer. "Together with the safety and tolerability results announced earlier this year from the same study, these new data support the advancement of Gelesis200." Gelesis also presented pharmacokinetic data for its lead, pivotal-stage product, Gelesis100, which showed that administration of Gelesis100 with metformin hydrochloride 850 mg (immediate release tablet) was safe, well-tolerated, and affected metformin pharmacokinetics similarly to food alone. Since metformin is typically administered with food, these results demonstrated that Gelesis100 could potentially be used safely for weight management in patients with type 2 diabetes who take metformin.
About Gelesis100 Gelesis100 capsules are taken with water prior to a meal, after which the thousands of small hydrogel particles in each capsule are released from the capsules in the stomach and rapidly absorb water, hydrating to approximately 100 times their original size. The hydrogel particles mix homogeneously with food and travel through the GI tract, inducing weight loss and improving glycemic control. Once in the large intestine, the particles release most of the water, which is reabsorbed by the body. The microscopic degraded particles are then safely eliminated by the body in the same manner as food.
About Gelesis200
About Gelesis The Gelesis advisory team is comprised of leading experts in obesity and its related comorbidities, clinical research and development and advanced biomaterials, including Caroline Apovian, M.D., Professor of Medicine and Pediatrics at Boston University School of Medicine; Louis J. Aronne, M.D., FACP, Director of the Comprehensive Weight Control Program at Weill Cornell Medicine; Arne Astrup, M.D., Head of Department of Nutrition, Exercise and Sports at University of Copenhagen; Ken Fujioka, M.D., Director of the Nutrition and Metabolic Research Center and the Center for Weight Management at the Scripps Clinic; Allan Geliebter, Ph.D., Senior Attending Psychologist, St. Luke's-Roosevelt Hospital; James Hill, Ph.D., Professor of Medicine and Pediatrics, University of Colorado; Lee M. Kaplan, M.D., Ph.D., Director of the Obesity, Metabolism and Nutrition Institute at Massachusetts General Hospital; Bennett Shapiro, M.D., Co-founder and Non-Executive Director at PureTech and former Executive Vice President of Research for Merck; and Angelo Tremblay, Ph.D., professor, Department of Kinesiology at Laval University. Some of these advisors hold equity in Gelesis. Gelesis shareholders include Cormorant Asset Management, PureTech Health PLC (LSE: PRTC), Invesco Asset Management, the Pritzker/Vlock Family Office, and other prominent biotech and finance leaders.
Forward Looking Statement
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