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BioXcel and Centrexion Therapeutics Further Advance Big Data Innovation Lab Collaboration in Chronic PainBRANFORD, Conn., Oct. 19, 2016 (GLOBE NEWSWIRE) -- BioXcel Corporation, a privately held biopharmaceutical company pioneering the integration of big data analytics and machine learning-based artificial intelligence (AI) with drug development expertise to advance the next wave of medicines, today announced receipt of its first development milestone payment from Centrexion Therapeutics. Centrexion is focused on advancing the treatment of moderate to severe chronic pain with one of the largest exclusively pain-focused pipelines of non-opioid therapies in active development. BioXcel’s Big Data Innovation Lab (BDI-Lab) generated product development blueprints for three novel small molecule pain drugs in Centrexion’s pipeline. The treatment of moderate to severe chronic pain represents a large market with several areas of unmet need for non-opioid alternatives. In less than 12 months, BioXcel’s big data analytics approach enabled the development of target product profiles for specific drug candidates across multiple pain-related indications. Under the collaboration, Centrexion is utilizing BioXcel’s proprietary BDI-Lab to generate optimal therapeutic value by deciphering the association of drug, disease, mechanism of action, and network-based pharmacology to further advance Centrexion’s non-opioid pain pipeline. Centrexion’s pursuit of targeted therapies for chronic pain consists of candidates originally acquired from Boehringer Ingelheim. These therapies aim to selectively interrupt pain transmission pathways, thereby addressing a significant need in the market. “This partnership has generated excellent results,” said Randall Stevens, M.D., Chief Medical Officer, Centrexion Therapeutics. “These productblueprints are an important step in our efforts to develop new, non-opioid therapies for chronic pain and bring novel treatments to patients in need. We look forward to our continued partnership with BioXcel as we work to redefine the clinical development of new pain therapies.” “The acceptance of these first three product blueprints by Centrexion is an important milestone for BioXcel and a critical validation of the ability of our BDI-Lab to translate clinical hypotheses into human therapies,” added Frank Yocca, Senior Vice President, CNS R&D, BioXcel. “Our BDI-Lab has tremendous potential in neuroscience indications, across a wide range of therapeutic areas that we are currently exploring through our internal pipeline development as well as collaboration agreements with partners in the industry.” “With our artificial Intelligence and machine learning capabilities, we aim to augment pharma R&D decisions across teams and support the development of better therapies, faster and more efficiently than ever before,” added Dr. Krishnan Nandabalan, President and Chief Scientific Officer of BioXcel. Centrexion will present further details of the collaboration at the 10th Annual Arrowhead Pain and Migraine Conference, being held October 19-20, 2016 in Chicago, IL. Dr. Stevens will be hosting a presentation titled The Integration of Artificial and Human Intelligence for Differentiated Pain Therapeutics on October 20 at 9:30am CDT. About Centrexion Therapeutics For more information about Centrexion, visit http://www.centrexion.com. About BioXcel For more information about BioXcel, visit http://www.bioxcel.com Contact Information: Anita Ganjoo, Ph.D. Corporate Communications 203 957 2487 |